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Guidelines

MIRAGE

CD47 molecule

Summary

Gene Symbol

CD47

Organism

Homo sapiens (human)

External Links

NCBI Gene

961

PubChem

961

Alliance of Genome Resources

HGNC:1682

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Apoptosis
Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Inflammatory response
Phosphoprotein
Pyrrolidone carboxylic acid
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q08722	Antigenic surface determinant protein OA3 Integrin-associated protein Protein MER6
A0A0A1TSG4	Integrin-associated protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
apoptotic process	IEA
inflammatory response	IEA
cell adhesion
integrin-mediated signaling pathway	TAS	8294396

GO Hierarchy

biological process

cellular process [inference]

cell-cell adhesion [inference]

heterotypic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to interleukin-1 [inference]

cellular response to interleukin-1

response to interleukin-12 [inference]

cellular response to interleukin-12

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organic anion transport [inference]

ATP transport [inference]

ATP export

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ATP transport [inference]

ATP export

adenine nucleotide transport [inference]

ATP transport [inference]

ATP export

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ATP transport [inference]

ATP export

adenine nucleotide transport [inference]

ATP transport [inference]

ATP export

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

ATP transport [inference]

ATP export

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ATP transport [inference]

ATP export

adenine nucleotide transport [inference]

ATP transport [inference]

ATP export

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of immune response [inference]

regulation of Fc receptor mediated stimulatory signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Fc receptor mediated stimulatory signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Fc receptor mediated stimulatory signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of immune response [inference]

regulation of Fc receptor mediated stimulatory signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Fc receptor mediated stimulatory signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of nitric oxide biosynthetic process

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

positive regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly [inference]

positive regulation of stress fiber assembly

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of monocyte extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of monocyte extravasation

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte extravasation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
cell surface	ISS
cell surface	NAS	25795378
cell surface	IDA	11509594

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protein binding	IPI	15383453 15917238 17070842 19004835 24026300 25416956 32296183 32814053 33961781 8550562
fibrinogen binding	IDA	22079249
thrombospondin receptor activity	IDA	8550562
thrombospondin receptor activity	IBA
thrombospondin receptor activity	IPI	15700281

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

protein binding involved in heterotypic cell-cell adhesion

protein-containing complex binding [inference]

fibrinogen binding

molecular transducer activity [inference]

signaling receptor activity [inference]

thrombospondin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Leukocyte surface antigen CD47

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
positive regulation of cell-cell adhesion
positive regulation of inflammatory response
positive regulation of phagocytosis
thrombospondin receptor activity

Displaying **all 7** entries
InterPro
CD47 immunoglobulin-like
CD47-like, transmembrane
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Leukocyte surface antigen CD47, IgV
Leukocyte surface antigen CD47

Ortholog

Displaying entries **21 - 30** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Papio anubis	101014343		PAPAN24041
Saimiri boliviensis boliviensis	101045637		SAIBB31604
Felis catus	101083027		FELCA23518
Ovis aries	101111153		SHEEP01337
Gorilla gorilla gorilla	101131909		GORGO29820
Tursiops truncatus	101338006		TURTR05056
Mustela putorius furo	101681023		MUSPF06213
Ficedula albicollis	101806784		FICAL08454
Chrysemys picta bellii	101950061		CHRPI32057
Macaca fascicularis	102139846		MACFA28067

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Last updated: December 8, 2025