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CD59 molecule (CD59 blood group)

Summary

Gene Symbol

CD59

Organism

Homo sapiens (human)

External Links

NCBI Gene

966

PubChem

966

Alliance of Genome Resources

HGNC:1689

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
GPI-anchor
Glycation
Hereditary hemolytic anemia
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6FHM9	MAC-inhibitory protein Membrane attack complex inhibition factor Protectin
P13987	1F5 antigen 20 kDa homologous restriction factor MAC-inhibitory protein MEM43 antigen Membrane attack complex inhibition factor Membrane inhibitor of reactive lysis Protectin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of activation of membrane attack complex	IBA
cell surface receptor signaling pathway	TAS	7691713
blood coagulation	TAS	1381503
regulation of complement activation	IDA	25284781
regulation of complement-dependent cytotoxicity	IDA	25284781

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cell killing [inference]

regulation of complement-dependent cytotoxicity

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
extracellular space	HDA	16502470
endoplasmic reticulum membrane	TAS
plasma membrane	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

secretory granule membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

secretory granule membrane [inference]

endoplasmic reticulum-Golgi intermediate compartment membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
complement binding	IBA
protein binding	IPI	17500595 20427317 24036449 32296183 32814053

GO Hierarchy

molecular function

binding [inference]

protein binding

complement binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CD59

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Ly-6 antigen/uPA receptor-like
Snake toxin-like superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	966	ZFIN:ZDB-GENE-030131-7871
Mus musculus	12509	RGD:2311	MOUSE34269
Rattus norvegicus	25407	ZFIN:ZDB-GENE-030131-7871	RATNO26254
Mus musculus	333883	ZFIN:ZDB-GENE-030131-7871	MOUSE34262
Sus scrofa	397347		PIGXX17451
Bos taurus	505574		BOVIN07387
Macaca mulatta	693402		MACMU10009
Macaca mulatta	693993		MACMU10009
Pan troglodytes	739046		PANTR02610
Oryctolagus cuniculus	100009459		RABIT01150

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements