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Guidelines

MIRAGE

endothelin converting enzyme 2

Summary

Gene Symbol

ECE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9718

PubChem

9718

Alliance of Genome Resources

HGNC:13275

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Metalloprotease
Methyltransferase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P0DPD8
P0DPD6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS
cell-cell signaling	TAS	11718899
brain development
heart development
cardioblast differentiation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

methylation

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	ISS
plasma membrane	IBA
transport vesicle membrane	ISS
transport vesicle membrane	TAS
cytoplasmic vesicle membrane	IDA	11718899

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

transport vesicle membrane

bounding membrane of organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA	11718899
metalloendopeptidase activity	IBA
protein binding	IPI	32296183
methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Ortholog

Displaying entries **61 - 70** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca fascicularis	107126442		MACFA26676
Sinocyclocheilus grahami	107561301		SINGR76882
Sinocyclocheilus grahami	107563005		SINGR87212
Ictalurus punctatus	108277812		ICTPU10084
Cebus imitator	108311073		CEBIM16638
Rhinopithecus bieti	108524964		RHIBE08792
Rhinopithecus bieti	108525021		RHIBE08792
Crocodylus porosus	109308496		CROPO15280
Phascolarctos cinereus	110221165		PHACI03324
Aotus nancymaae	110566983		AOTNA25882

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025