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MIRAGE
SET domain containing 1A, histone lysine methyltransferase

Summary
Gene Symbol
  • SETD1A
Organism
Homo sapiens (human)
NCBI Gene
9739
PubChem
9739
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Activator
  • Chromatin regulator
  • Chromosome
  • Cytoplasm
  • DNA damage
  • Disease variant
  • Epilepsy
  • Intellectual disability
  • Methyltransferase
  • Nucleus
  • Phosphoprotein
  • RNA-binding
  • Reference proteome
  • S-adenosyl-L-methionine
  • Transcription regulation
Proteins
Displaying 1 entry
UniProt Protein Name
O15047
  • Lysine N-methyltransferase 2F
  • SET domain-containing protein 1A
  • Set1/Ash2 histone methyltransferase complex subunit SET1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 7 in total
GO Term Evidence Code PMID
chromatin remodeling
DNA damage response
cellular response to DNA damage stimulus
brain development
methylation
GO Hierarchy
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
RNA binding
protein binding
beta-catenin binding
histone H3K4 methyltransferase activity
histone H3K4 methyltransferase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
histone-lysine n-methyltransferase
Functional Category
  • J: Translation, ribosomal structure and biogenesis
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying all 3 entries
Gene Ontology
histone H3K4 methyltransferase activity
methylation
transferase activity
Displaying all 9 entries
InterPro
COMPASS complex Set1 subunit, N-SET domain
Histone-lysine N-methyltransferase SETD1A/B-like, SET domain
Histone-lysine N-methyltransferase Set1-like
Nucleotide-binding alpha-beta plait domain superfamily
Post-SET domain
RNA recognition motif domain
RNA-binding domain superfamily
SET domain superfamily
SET domain
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:0070417 neurodevelopmental disorder with speech impairment and dysmorphic facies
DOID:0070471 early-onset epilepsy 2
Ortholog
Displaying entries 1 - 10 of 49 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
9739 Xenbase:XB-GENE-6046043
208043 SGD:S000001161
233904 Xenbase:XB-GENE-6046043 MOUSE53356
309001 RATNO17918
468101 PANTR12196
489916 CANLF16375
556535 DANRE31504
712416 MACMU27007
782887 BOVIN20633
100013387 MONDO28406
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025