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lysine methyltransferase 2B
Summary
- Gene Symbol
-
- KMT2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Chromatin regulator
- DNA-binding
- Disease variant
- Dystonia
- Intellectual disability
- Isopeptide bond
- Methyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- S-adenosyl-L-methionine
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9UMN6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromatin remodeling | ||
| methylation | ||
| positive regulation of transcription, DNA-templated | ||
| positive regulation of DNA-templated transcription |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nucleoplasm | ||
| histone methyltransferase complex | ||
| histone methyltransferase complex | ||
| MLL1/2 complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| zinc ion binding | ||
| histone H3K4 methyltransferase activity | ||
| histone H3K4 methyltransferase activity | ||
| histone H3K4 methyltransferase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- histone-lysine n-methyltransferase
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| histone H3K4 methyltransferase activity |
| metal ion binding |
| methylation |
| transferase activity |
| zinc ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | |
| DOID:0060936 | dystonia 28, childhood-onset | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1991 | Xenbase:XB-GENE-5805214 | ||
| 4297 | FB:FBgn0003862 | ||
| 5657 | Xenbase:XB-GENE-5805214 | ||
| 9757 | Xenbase:XB-GENE-853845 | ||
| 19152 | Xenbase:XB-GENE-5805214 | ||
| 41737 | Xenbase:XB-GENE-853845 | ||
| 50701 | Xenbase:XB-GENE-5805214 | ||
| 75410 | Xenbase:XB-GENE-5805214 | MOUSE55490 | |
| 455959 | PANTR18021 | ||
| 612999 | CANLF01190 |
