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Guidelines

MIRAGE

signal peptidase complex subunit 2

Summary

Gene Symbol

SPCS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9789

PubChem

9789

Alliance of Genome Resources

HGNC:28962

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Endoplasmic reticulum
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15005	Microsomal signal peptidase 25 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signal peptide processing	IDA	34388369
signal peptide processing	IBA
protein targeting to ER	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signal peptidase complex	IBA
signal peptidase complex	IPI	34388369
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	34388369

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

signal peptidase complex

endoplasmic reticulum protein-containing complex [inference]

signal peptidase complex

catalytic complex [inference]

peptidase complex [inference]

signal peptidase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	34232536 34388369

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Signal peptidase complex subunit 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
protein targeting to ER
signal peptide processing

Displaying 1 entry
InterPro
Signal peptidase complex subunit 2

Ortholog

Displaying entries **1 - 10** of 49 in total

1

2

3

4

5

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9789	Xenbase:XB-GENE-5826459
Mus musculus	66624		MOUSE55226
Rattus norvegicus	293142		RATNO21073
Canis lupus familiaris	404016		CANLF08267
Macaca mulatta	694179		MACMU11500
Macaca mulatta	707684		MACMU11500
Pan troglodytes	748664		PANTR03832
Pongo abelii	100172541		PONAB03432
Ciona intestinalis	100178515		CIOIN16371
Callithrix jacchus	100402872		CALJA03982

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025