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cytoskeleton associated protein 5

Summary

Gene Symbol

CKAP5

Organism

Homo sapiens (human)

External Links

NCBI Gene

9793

PubChem

9793

Alliance of Genome Resources

HGNC:28959

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Cytoskeleton
Kinetochore
Mitosis
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14008	Colonic and hepatic tumor overexpressed gene protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
microtubule depolymerization	TAS	26323690
spindle organization	IMP	14718566
mitotic spindle organization	IBA
centrosome cycle	IMP	14718566
establishment or maintenance of microtubule cytoskeleton polarity	IMP	14718566

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization

mitotic spindle organization

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

microtubule organizing center organization [inference]

centrosome cycle

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cell cycle process [inference]

spindle organization

mitotic spindle organization

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization

mitotic spindle organization

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

microtubule organizing center organization [inference]

centrosome cycle

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

establishment of RNA localization [inference]

RNA transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	25596274
kinetochore	IBA
spindle pole	IDA	21646404
spindle pole	IBA
nucleolus	IDA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

cytosol

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

kinetochore

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11903063 14603251 15703215 17474147 20360068 21297582 26496610 33961781
microtubule binding	IDA	10770946
microtubule binding	IBA
ribonucleoprotein complex binding	IDA	15703215
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

microtubule plus end polymerase

catalytic activity, acting on a protein [inference]

microtubule plus end polymerase

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

microtubule plus-end binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytoskeleton-associated protein 5

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
centrosome duplication
establishment or maintenance of microtubule cytoskeleton polarity
microtubule binding
microtubule plus end polymerase
microtubule plus-end binding
microtubule polymerization
tubulin binding

Displaying **all 6** entries
InterPro
Armadillo-like helical
Armadillo-type fold
CLASP N-terminal domain
TOG domain
XMAP215/Dis1/CLASP, TOG domain
XMAP215

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9793	Xenbase:XB-GENE-5871815
Mus musculus	75786	Xenbase:XB-GENE-5871815	MOUSE32946
Rattus norvegicus	311191		RATNO29086
Pan troglodytes	451160		PANTR02768
Canis lupus familiaris	475986		CANLF05859
Danio rerio	492614		DANRE27507
Bos taurus	533980		BOVIN07510
Macaca mulatta	714095		MACMU10143
Xenopus tropicalis	850734	Xenbase:XB-GENE-5871815
Monodelphis domestica	100011933		MONDO27889