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cytoskeleton associated protein 5

Summary

Gene Symbol

CKAP5

Organism

Homo sapiens (human)

External Links

NCBI Gene

9793

PubChem

9793

Alliance of Genome Resources

HGNC:28959

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Cytoskeleton
Kinetochore
Mitosis
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14008	Colonic and hepatic tumor overexpressed gene protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
microtubule depolymerization	TAS	26323690
spindle organization	IMP	14718566
mitotic spindle organization	IBA
centrosome cycle	IMP	14718566
establishment or maintenance of microtubule cytoskeleton polarity	IMP	14718566

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization

mitotic spindle organization

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

microtubule organizing center organization [inference]

centrosome cycle

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cell cycle process [inference]

spindle organization

mitotic spindle organization

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization

mitotic spindle organization

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

microtubule organizing center organization [inference]

centrosome cycle

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

establishment of RNA localization [inference]

RNA transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization [inference]

positive regulation of microtubule nucleation

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
cilium	IDA
microtubule cytoskeleton	ISS	15703215
membrane	HDA	19946888
protein-containing complex	IDA	18468998
microtubule plus-end	IDA	21646404

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

cytosol

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

kinetochore

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11903063 14603251 15703215 17474147 20360068 21297582 26496610 33961781
microtubule binding	IDA	10770946
microtubule binding	IBA
ribonucleoprotein complex binding	IDA	15703215
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

microtubule plus end polymerase

catalytic activity, acting on a protein [inference]

microtubule plus end polymerase

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

microtubule plus-end binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytoskeleton-associated protein 5

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
establishment or maintenance of microtubule cytoskeleton polarity
microtubule binding
microtubule plus end polymerase
microtubule plus-end binding
microtubule polymerization
tubulin binding

Displaying **all 5** entries
InterPro
Armadillo-like helical
Armadillo-type fold
TOG domain
XMAP215/Dis1/CLASP, TOG domain
XMAP215

Ortholog

Displaying entries **11 - 20** of 77 in total

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Species	Gene ID	Orthologous MAtrix
Equus caballus	100050886	HORSE05193
Ornithorhynchus anatinus	100080667	ORNAN19139
Taeniopygia guttata	100228646	TAEGU26058
Oryctolagus cuniculus	100351133	RABIT01212
Callithrix jacchus	100386801	CALJA04261
Pongo abelii	100431543	PONAB03257
Ailuropoda melanoleuca	100473125	AILME10329
Sus scrofa	100519182	PIGXX17331
Nomascus leucogenys	100595802	NOMLE10580
Loxodonta africana	100675479	LOXAF12377