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cell division cycle 27

Summary

Gene Symbol

CDC27

Organism

Homo sapiens (human)

External Links

NCBI Gene

996

PubChem

996

Alliance of Genome Resources

HGNC:1728

Annotation

Keyword

3D-structure
Alternative splicing
Cell division
Cytoskeleton
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
TPR repeat
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G5EA36
B4DL80
P30260	Anaphase-promoting complex subunit 3 CDC27 homolog H-NUC

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
metaphase/anaphase transition of mitotic cell cycle	IMP	7736578
metaphase/anaphase transition of mitotic cell cycle	IBA
regulation of mitotic cell cycle	NAS	15678131
protein ubiquitination	IBA
anaphase-promoting complex-dependent catabolic process	NAS	15678131

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

cellular process [inference]

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

metaphase/anaphase transition of mitotic cell cycle

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

metaphase/anaphase transition of mitotic cell cycle

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

regulation of meiotic cell cycle

regulation of reproductive process [inference]

regulation of meiotic cell cycle

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	18445686 21241890
nucleoplasm	TAS
nucleoplasm	IDA
anaphase-promoting complex	NAS	27120157
anaphase-promoting complex	IDA	16364912 21926987

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10548110 16648845 17443180 17443186 17474147 17719540 18662541 20212161 20360068 20439707 20802534 20951947 21186364 21241890 21300909 21772247 22014574 23708001 24781523 25383541 25416956 25609649 26083744 26496610 33961781 35271311
protein phosphatase binding	IPI	21241890

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

anaphase promoting complex subunit

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell division
metaphase/anaphase transition of mitotic cell cycle
protein ubiquitination

Displaying **all 2** entries
InterPro
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	996	Xenbase:XB-GENE-972658
Danio rerio	30450		DANRE30936
Mus musculus	217232		MOUSE05764
Rattus norvegicus	360643		RATNO00635
Pan troglodytes	454815		PANTR13622
Canis lupus familiaris	490924		CANLF18515
Bos taurus	540660		BOVIN13598
Macaca mulatta	717321		MACMU15273
Monodelphis domestica	100025278		MONDO12055
Ornithorhynchus anatinus	100092325		ORNAN03380