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Guidelines

MIRAGE

THO complex subunit 1

Summary

Gene Symbol

THOC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9984

PubChem

9984

Alliance of Genome Resources

HGNC:19070

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Apoptosis
Cytoplasm
DNA-binding
Disease variant
Isopeptide bond
Non-syndromic deafness
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Transcription regulation
Ubl conjugation
mRNA splicing
mRNA transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96FV9	Nuclear matrix protein p84 hTREX84

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mRNA processing	IEA
mRNA export from nucleus	IMP	22144908
mRNA export from nucleus	IBA
apoptotic process	IEA
signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
transcription export complex	IDA	15833825 15998806
THO complex	IDA	15998806
THO complex part of transcription export complex	IDA	15998806
THO complex part of transcription export complex	IBA
chromosome, telomeric region	IDA	24270157

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription export complex

THO complex part of transcription export complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
RNA binding	IEA
protein binding	IPI	15870275 19059247 19165146 22365833 23299939 25416956 26496610 28514442 31515488 32296183 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tHO complex

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
mRNA export from nucleus
regulation of DNA-templated transcription elongation

Displaying **all 3** entries
InterPro
Death domain
Death-like domain superfamily
THO complex, subunit THOC1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070610	autosomal dominant nonsyndromic deafness 86	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025