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NAD-dependent protein deacetylase sirtuin-1

Summary

UniProt ID

A0A0G2JZ79

Gene Symbol

Sirt1

Organism

Rattus norvegicus (Norway rat)

External Links

The O-GlcNAc Database: A0A0G2JZ79

Annotation

Keyword

Acetylation
Apoptosis
Biological rhythms
Cytoplasm
Developmental protein
Differentiation
Metal-binding
Methylation
Myogenesis
NAD
Nucleus
Phosphoprotein
Reference proteome
S-nitrosylation
Transcription regulation
Transferase
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
positive regulation of skeletal muscle cell proliferation
positive regulation of macroautophagy
response to nutrient levels
negative regulation of tumor necrosis factor production
response to insulin
regulation of smooth muscle cell apoptotic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus

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GO Term
eNoSc complex
PML body
growth cone
mitochondrion
cytosol
nucleoplasm
nuclear inner membrane
chromatin silencing complex
rDNA heterochromatin
ESC/E(Z) complex

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GO Term
DNA-binding transcription factor binding
keratin filament binding
promoter-specific chromatin binding
nuclear receptor binding
NAD-dependent histone deacetylase activity
protein domain specific binding
NAD-dependent histone H3K14 deacetylase activity
NAD-dependent protein deacetylase activity
identical protein binding
HLH domain binding

Annotation information from UniProt.

Sequence

MIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQELTDVNCTPDKSEHY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Regulation of FOXO transcriptional activity by acetylation	Rattus norvegicus
Regulation of HSF1-mediated heat shock response	Rattus norvegicus
SIRT1 negatively regulates rRNA expression	Rattus norvegicus