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Prothrombin

Summary

UniProt ID: A0A851F0Q1
Gene Symbol: F2 PITSOR_R10672
Gene ID
Organism: Pitta sordida (hooded pitta)

External Links

Re-Glyco: A0A851F0Q1

Annotation

Keyword: Acute phase Calcium Cleavage on pair of basic residues Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Kringle Reference proteome Repeat Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF
acute-phase response
platelet activation	IEA	GO_REF
positive regulation of blood coagulation	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

cell activation [inference]

platelet activation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying 1 entry
GO Term	Evidence Code	Reference
obsolete extracellular space

GO Hierarchy

cellular component

Displaying **all 2** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	IEA	GO_REF GO_REF GO_REF GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEHTKASILRGLLFYSLLHLTLSHAGVFLEKGQALSLLKRPRRANSGFVEEMLKGNLERECLEETCSYEEAFEALESIDQTVAFWSKYQLCQGPRTPRTALDACLEGSCSFGLGQNYRGTINYTKSGIECQVWTSKYPHIPKFNATIFPNLIENYCRNPDNNSEGPWCYTRDPSVEREECPIPVCGQERTTVPFTPRPTPPPPVEPCEQEKGTLYTGTLSVTVSGAKCLPWNSEKAKEVLYGKHLDPEVKLLENYCRNPDRDDEGVWCVTADPPYFDYCDLQYCDSSLEDENEEPERMSGRSTRPQEFKTFFDVKTFGSGEADCGTRPLFEKKKVTDKTEKELLESYRGGRIVHGDDAEVGSSPWQVMIFKKTPQELLCGASLISDSWILTAAHCLYYPPWDKNLTTNDILVRIGKHVRAKYEKSKEKIALLDKIIIHPKYNWKENMDRDIALMHLRRPVIFSDYIHPVCLPTKEIVQRLMLAGYKGRVTGWGNLKETWATSPSNLPTVLQQLNVPIVDQSICKASTKIKITDNMFCAGYSPEDSRRGDSCEGDSGGPFVMKNPEDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMLKVIEKHG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
122	N-linked (GlcNAc...) (complex) asparagine	UniProt
144	N-linked (GlcNAc...) (complex) asparagine	UniProt
404	N-linked (GlcNAc...) (complex) asparagine	UniProt