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Sterol regulatory element-binding protein cleavage-activating protein

Summary

UniProt ID: A2RRU4
Gene Symbol: Scap
Gene ID: 301024
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: A2RRU4
Re-Glyco: A2RRU4

Annotation

Keyword: Cholesterol metabolism Cytoplasmic vesicle Endoplasmic reticulum Glycoprotein Golgi apparatus Isopeptide bond Lipid-binding Methylation Phosphoprotein Reference proteome Repeat Transmembrane helix Ubl conjugation WD repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
response to hypoxia	ISO	GO_REF
lipid metabolic process	ISO	GO_REF
immune response	ISO	GO_REF
cholesterol metabolic process	ISS	GO_REF
cholesterol metabolic process	ISO	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

immune response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle cargo loading [inference]

COPII-coated vesicle cargo loading

intracellular transport [inference]

COPII-coated vesicle cargo loading

establishment of localization in cell [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
Golgi membrane	ISS	GO_REF
Golgi membrane	ISO	GO_REF
Golgi membrane	IEA	GO_REF GO_REF GO_REF
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

SREBP-SCAP complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
sterol binding	ISS	GO_REF
sterol binding	IEA	GO_REF
protein-containing complex binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding

protein-containing complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
263	N-linked (GlcNAc...) asparagine	UniProt
590	N-linked (GlcNAc...) asparagine	UniProt
641	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Regulation of cholesterol biosynthesis by SREBP (SREBF)	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements