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A disintegrin and metallopeptidase domain 17

Summary

UniProt ID

E9PXU2

Gene Symbol

Adam17

Gene ID

11491

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0002412
Re-Glyco: E9PXU2

Annotation

Keyword

Disulfide bond
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Proteomics identification
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
cell-cell junction
actin cytoskeleton
cytosol
cell surface
apical plasma membrane
focal adhesion
ruffle membrane
membrane raft

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 23 in total

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GO Term
response to hypoxia
membrane protein ectodomain proteolysis
negative regulation of transforming growth factor beta receptor signaling pathway
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
positive regulation of blood vessel endothelial cell migration
positive regulation of vascular endothelial cell proliferation
Notch receptor processing
positive regulation of T cell chemotaxis
wound healing, spreading of epidermal cells

Displaying **all 7** entries
GO Term
interleukin-6 receptor binding
PDZ domain binding
tumor necrosis factor binding
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Notch binding
metal ion binding
integrin binding

Annotation information from UniProt.

Sequence

MRRRLLILTTLVPFVLAPRPPEEAGSGSHPRLEKLDSLLSDYDILSLANIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLGYISGTRDRVTTDCFLEFLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPTVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACVDTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVPAAPKLDHQRMDTIQEDPSTDSHADDDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites