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A disintegrin and metalloproteinase with thrombospondin motifs 5

Summary

UniProt ID: G5C6W7
Gene Symbol: Adamts5 GW7_07225
Gene ID: 101698184
Organism: Heterocephalus glaber (naked mole-rat)

External Links

Re-Glyco: G5C6W7

Annotation

Keyword: Calcium Cleavage on pair of basic residues Disulfide bond Extracellular matrix Glycoprotein Integrin Metal-binding Metalloprotease Reference proteome Signal Zinc Zymogen

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF GO_REF
integrin-mediated signaling pathway
extracellular matrix organization	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	Reference
extracellular region
extracellular matrix	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	IEA	GO_REF GO_REF
zinc ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLLGWAPLLLCAFRLPLAVASPAAAPAQEKARQPRAAAAAAQPRQRQGEEAQLRVEPPGHPRALAPAPQHGSRGLVRNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSLGAAGFVPAGGGLSVPGQHGGHCFYRGTVDGSPRSLAVFDLCGGLQGFFAVKHARYTVKPLLRGPWAEAETGRVYGDGSARILHVYTREGFAFEALPPHASCETPASRPGPHKRPPAHNSPGRQAALAPQLPDQPTLLPAGDPGPQTWWRRRRRSISRARQVELLLVADASMAKMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKSFCKWQHQHNQLGDDHDEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAHRHCNNPAPRNSGRYCTGKRAIYRSCNVLPCPPNDKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKVIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKSGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKSTPAVNSVTSHGSNKVGLHTPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCLLSQRPSAFKQCLLKKC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites