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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal alpha-mannosidase
Summary
- UniProt ID
- O00754
- Gene Symbol
-
- MAN2B1
- LAMAN
- MANB
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011174
- GlyConnect
- GlyGen
- O00754
- PubChem
- O00754
- The Human Metabolome Database
- HMDBP11810
- The O-GlcNAc Database
- O00754
- RaftProt
- O00754
- O-GlcNAcAtlas
- O00754
Annotation
- Keyword
-
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lysosome
- Metal-binding
- Reference proteome
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| mannose metabolic process |
| N-glycan processing |
| oligosaccharide catabolic process |
| learning or memory |
| protein modification process |
| protein deglycosylation |
| GO Term |
|---|
| metal ion binding |
| carbohydrate binding |
| alpha-mannosidase activity |
Sequence
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 133 | N-linked (GlcNAc...) asparagine | |||
| 310 | N-linked (GlcNAc...) asparagine | |||
| 367 | N-linked (GlcNAc...) asparagine | |||
| 371 |
|
|||
| 497 | N-linked (GlcNAc...) asparagine | |||
| 645 | N-linked (GlcNAc...) asparagine | |||
| 651 | N-linked (GlcNAc...) asparagine | |||
| 692 | N-linked (GlcNAc...) asparagine | |||
| 766 | N-linked (GlcNAc...) asparagine | |||
| 774 |
|
|
G45395BF
G08290VR
G47644PP
G92275SC
G41247ZX
G02815KT
G28681TP
G82443XX
G46691LC
G83460ZZ
G80920RR
G62765YT
G05724UK
G31852PQ
G90575OW
G39188ZX
G50282JC
G06110VR
G14669DU
G49108TO
G77277QT
G08918WF
G00912UN
G48414YA
G41071NU
G59626AS
G20210JR
G23294PN
G01485JJ
G65184UU
G42124LM
G02886BB
G72790NZ
G10486CT
G90734RJ
G85269DF
G72291OX
G95865ZB
G49955PK
G72787SB
G35029YA
G57776ZU
G57317CE
G92050GC
G27058EU
G01650EU
G12313PD
G29299MO
G37399XV
G82463GQ
G47950XN
G62894KT
G11870QZ
G05049YU
G55383ZG
G11314AS
G74724QE
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Lysosomal oligosaccharide catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14500 | fucosidosis | |
| DOID:0050461 | aspartylglucosaminuria | |
| DOID:0060320 | inguinal hernia | |
| DOID:0060740 | methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:10426 | Klippel-Feil syndrome | |
| DOID:1059 | intellectual disability | |
| DOID:10871 | age related macular degeneration | |
| DOID:11771 | spontaneous ocular nystagmus |
