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Leptin receptor

Summary

UniProt ID: O02671
Gene Symbol: LEPR OBR
Gene ID: 396836
Organism: Sus scrofa (pig)

External Links

Re-Glyco: O02671

Annotation

Keyword: Cell membrane Disulfide bond Glycoprotein Obesity Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
angiogenesis	ISS	GO_REF
phagocytosis	ISS	GO_REF
positive regulation of cell population proliferation	IBA	GO_REF
negative regulation of autophagy	ISS	GO_REF
cytokine-mediated signaling pathway	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

leptin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

reproductive process [inference]

sexual reproduction

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

organ growth [inference]

bone growth

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

growth [inference]

developmental growth [inference]

organ growth [inference]

bone growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to leptin

response to chemical [inference]

response to hormone [inference]

response to leptin

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

leptin-mediated signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of autophagy [inference]

negative regulation of autophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling

regulation of behavior [inference]

regulation of feeding behavior

Displaying **all 3** entries
GO Term	Evidence Code	Reference
external side of plasma membrane	IBA	GO_REF
basolateral plasma membrane	IEA	GO_REF
signaling receptor complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
cytokine receptor activity	IBA	GO_REF
cytokine receptor activity	IEA	GO_REF
cytokine binding	IBA	GO_REF
leptin receptor activity	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

leptin receptor activity

immune receptor activity [inference]

cytokine receptor activity

leptin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTCPKFSVALLHWEFIYVITAFDLAYPITPWKFKLSCMPPNTTYDFLLPAGISKNTSTLNGHDEAVVETELNSSGTYLSNLSSKTTFHCCFWSEEDKNCSVHADNIAGKAFVSAVNSLVFQQTGANWNIQCWMKEDLKLFICYMESLFKNPFKNYDLKVHLLYVLLEVLEGSPLLPQKGSFQSVQCNCSARECCECHVPVSAAKLNYTLLMYLKITSGGAVFHSPLMSVQPINVVKPDPPLGLHMEITDTGNLKISWSSPTLVPFQLQYQVKYSENSTTNMREADEIVSDTSLLVDSVLPGSSYEVQVRGKRLDGPGIWSDWSTPFTFTTQDVIYFPPKILTSVGSNISFHCIYKNENKIVSSKKIVWWMNLAEKIPQSQYDVVGDHVSKVTFPNMNATKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTNAIQSLVGSTLQLRYHRSSLYCSDVPSVHPISEPKDCQLQRDGFYECIFQPIFLLSGYTMWIRINHPLGSLDSPPTCVIPDSVVKPLPPSSVKAEITAKIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKIYEVYDTKLKSTSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSTPAYTVVTDVKVPIRGPEFWRIINEDATKKERNITLLWKPLMKNDSLCSVRSYVVKHHTSRHGTWSEDVGNHTKLTFLWTEQAHSVTVLAVNSIGASSANFNLTFSWPMSKVNIVQSLSAYPLNSSCVGLSWLLSPSDYNLMYFILEWKILNEDHEIKWLRIPSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDGEKHRNDAGLYVIVPIIISSSILLLGTLLMSHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTESVTFGPLLLEPETISEDISVDTSWKNKDEMVPPTTVSLLLTTPDLEKSSICISDQRSSAHFSEAESMEITREDENRRQPSIKYATLLSSPKSGETEQEQELVSSLVSRCFSSSNSLPKESFSNSSWEIETQAFFILSDQHPNMTSPHLSFSEGLDELMKFEGNFPKEHNDERSVYYLGVTSIKKRESDVFLTDESRVRCPFPAHCLFADIKILQESCSHLVENNFNLGTSGQKTFVSYMPQFQTCSTQTQKIMENKMYDLTV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 17 in total

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Position	Description	Source
41	N-linked (GlcNAc...) asparagine	UniProt
55	N-linked (GlcNAc...) asparagine	UniProt
72	N-linked (GlcNAc...) asparagine	UniProt
80	N-linked (GlcNAc...) asparagine	UniProt
98	N-linked (GlcNAc...) asparagine	UniProt
187	N-linked (GlcNAc...) asparagine	UniProt
206	N-linked (GlcNAc...) asparagine	UniProt
276	N-linked (GlcNAc...) asparagine	UniProt
347	N-linked (GlcNAc...) asparagine	UniProt
397	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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