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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Disintegrin and metalloproteinase domain-containing protein 10
Summary
- UniProt ID
- O14672
- Gene Symbol
-
- ADAM10
- KUZ
- MADM
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloidosis
- Cell junction
- Cell membrane
- Cell projection
- Cleavage on pair of basic residues
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Metal-binding
- Metalloprotease
- Neurodegeneration
- Notch signaling pathway
- Phosphoprotein
- Reference proteome
- SH3-binding
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| endoplasmic reticulum lumen |
| Golgi apparatus |
| Golgi-associated vesicle |
| adherens junction |
| cell surface |
| clathrin-coated vesicle |
| perinuclear endoplasmic reticulum |
| nucleus |
| cytoplasm |
| GO Term |
|---|
| metallodipeptidase activity |
| metalloendopeptidase activity involved in amyloid precursor protein catabolic process |
Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 397 |
|
|||
| 439 | N-linked (GlcNAc...) asparagine | |||
| 441 |
|
|||
| 551 | N-linked (GlcNAc...) asparagine |
|
||
| 556 |
|
|
G57321FI
G83460ZZ
G59626AS
G01650EU
G80920RR
G59924QI
G62765YT
G64527OM
G28541PG
G05724UK
G31852PQ
G39188ZX
G41247ZX
G02815KT
G06110VR
G92050GC
G49108TO
G80075MS
G86880BF
G90382BL
G87123QX
G79666IR
G92135MA
G98611JV
G34989PA
G40834TG
G45395BF
G40926MX
G14972EH
G43223CG
G10846ZT
G00273SJ
G08918WF
G00912UN
G70441OD
G87661QW
G83646BJ
G76295SF
G46691LC
G27126ED
G04657PL
G27058EU
G41071NU
G72747WU
G70619PT
G65184UU
G42124LM
G90659AW
G95865ZB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
| Regulation of IGF Activity by IGFBP | Homo sapiens |
| Signaling by EGFR | Homo sapiens |
