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Tripeptidyl-peptidase 1

Summary

UniProt ID

O14773

Gene Symbol

TPP1
CLN2

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011177

GlyConnect

1858

GlyGen

O14773

PubChem

O14773

The Human Metabolome Database

HMDBP14587

RaftProt

O14773

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Lysosome
Metal-binding
Neuronal ceroid lipofuscinosis
Reference proteome
Serine protease
Signal
Spinocerebellar ataxia
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

1

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GO Term
proteolysis
lipid metabolic process
nervous system development
central nervous system development
epithelial cell differentiation
bone resorption
neuromuscular process controlling balance
protein localization to chromosome, telomeric region
lysosomal protein catabolic process
lysosome organization

Displaying **all 7** entries
GO Term
Golgi apparatus
lysosome
melanosome
membrane raft
recycling endosome
lysosomal lumen
extracellular exosome

Displaying **all 9** entries
GO Term
endopeptidase activity
peptidase activity
serine-type peptidase activity
tripeptidyl-peptidase activity
peptide binding
serine-type endopeptidase activity
metal ion binding
lysophosphatidic acid binding
sulfatide binding

Annotation information from UniProt.

Sequence

MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
193			G57321FI	GlyGen
210	N-linked (GlcNAc...) asparagine	19038966 19038967 19159218	G64394MX G70375MX G80735OA	UniProt GlyGen GlyConnect
222	N-linked (GlcNAc...) asparagine	19159218	G11719TC	UniProt GlyGen
223				GlyGen
286	N-linked (GlcNAc...) asparagine	19038966 19038967	G28622IK G34989PA G43669FQ G31852PQ G41247ZX G50282JC G02815KT G84349RE G28681TP	UniProt GlyGen
313	N-linked (GlcNAc...) asparagine	19038966 19038967 19159218	G01485JJ G39188ZX G06110VR G14669DU	UniProt GlyGen GlyConnect
443	N-linked (GlcNAc...) asparagine	12754519 19038966 19038967 19159218	G08918WF G00912UN G11870QZ G72291OX G74724QE G92275SC G14669DU G28681TP	GlycoProtDB UniProt GlyGen GlyConnect