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Intermediate conductance calcium-activated potassium channel protein 4

Summary

UniProt ID: O15554
Gene Symbol: KCNN4 IK1 IKCA1 KCA4 SK4
Gene ID: 3783
Organism: Homo sapiens (human)

External Links

GlyGen: O15554
PubChem: O15554
The Human Metabolome Database: HMDBP07760
RaftProt: O15554
Re-Glyco: O15554

Annotation

Keyword: 3D-structure Calmodulin-binding Cell membrane Cell projection Disease variant Hereditary hemolytic anemia Immunity Ion channel Phosphoprotein Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
immune system process
potassium ion transport	TAS	PMID
potassium ion transport	IEA	GO_REF
calcium ion transport	IDA	PMID
cell volume homeostasis

GO Hierarchy

biological process

immune system process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

response to stimulus [inference]

response to stress [inference]

defense response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

calcium ion transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

secretion [inference]

body fluid secretion [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

import into cell [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of calcium ion transport [inference]

regulation of calcium ion import [inference]

regulation of calcium ion import across plasma membrane

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of antigen receptor-mediated signaling pathway [inference]

positive regulation of T cell receptor signaling pathway

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of biological quality [inference]

regulation of membrane potential [inference]

stabilization of membrane potential

regulation of body fluid levels [inference]

body fluid secretion [inference]

saliva secretion

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
cytosol
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID PMID PMID GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
potassium channel activity	TAS	Reactome
potassium channel activity	IEA	GO_REF
calmodulin binding	IDA	PMID
calmodulin binding	IBA	GO_REF
calmodulin binding	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

calcium-activated potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

monoatomic ion-gated channel activity [inference]

calcium-activated cation channel activity [inference]

calcium-activated potassium channel activity

binding [inference]

protein binding [inference]

calmodulin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
423		36580660	G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Ca activated K+ channels	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:0001816	angiosarcoma	Alliance of Genome Resources
DOID:0111577	dehydrated hereditary stomatocytosis 2	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements