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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
NPC intracellular cholesterol transporter 1
Summary
- UniProt ID
- O35604
- Gene Symbol
-
- Npc1
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003118
- GlyConnect
- GlyGen
- O35604
- PubChem
- O35604
- SwissLipids
- RaftProt
- O35604
Annotation
- Keyword
-
- Cholesterol metabolism
- Disulfide bond
- Endosome
- Glycoprotein
- Lipid transport
- Lysosome
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cholesterol efflux |
| cholesterol homeostasis |
| viral entry into host cell |
| negative regulation of TORC1 signaling |
| liver development |
| adult walking behavior |
| negative regulation of macroautophagy |
| gene expression |
| lysosomal transport |
| protein glycosylation |
| GO Term |
|---|
| membrane raft |
| lysosomal membrane |
| late endosome membrane |
| GO Term |
|---|
| lipid transporter activity |
| cholesterol binding |
Sequence
MGAHHPALGLLLLLLCPAQVFSQSCVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQRAWAWEKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTYERYRGTERERLLNF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 524 | N-linked (GlcNAc...) asparagine |
|
||
| 598 |
|
|||
| 868 | N-linked (GlcNAc...) asparagine | |||
| 898 | N-linked (GlcNAc...) asparagine |
|
||
| 916 | N-linked (GlcNAc...) asparagine |
|
||
| 961 | N-linked (GlcNAc...) asparagine | |||
| 968 | N-linked (GlcNAc...) asparagine | |||
| 1063 | N-linked (GlcNAc...) asparagine |
G11314AS
G07246CJ
G26436YP
G86234IN
G70101JE
G80920RR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Mus musculus |
