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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
NPC intracellular cholesterol transporter 1
Summary
- UniProt ID
- O35604
- Gene Symbol
-
- Npc1
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003118
- GlyConnect
- GlyGen
- O35604
- PubChem
- O35604
- SwissLipids
- The O-GlcNAc Database
- O35604
- RaftProt
- O35604
Annotation
- Keyword
-
- Cholesterol metabolism
- Disulfide bond
- Endosome
- Glycoprotein
- Lipid transport
- Lysosome
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cholesterol efflux |
| intracellular cholesterol transport |
| negative regulation of TORC1 signaling |
| GO Term |
|---|
| endosome |
| endoplasmic reticulum |
| perinuclear region of cytoplasm |
| GO Term |
|---|
| lipid transporter activity |
| cholesterol binding |
Sequence
MGAHHPALGLLLLLLCPAQVFSQSCVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQRAWAWEKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTYERYRGTERERLLNF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 70 | N-linked (GlcNAc...) asparagine |
|
||
| 122 | N-linked (GlcNAc...) asparagine |
|
||
| 137 | N-linked (GlcNAc...) asparagine |
|
||
| 185 | N-linked (GlcNAc...) asparagine |
|
||
| 222 | N-linked (GlcNAc...) asparagine | |||
| 228 | N-linked (GlcNAc...) asparagine | |||
| 314 |
|
|||
| 414 | N-linked (GlcNAc...) asparagine | |||
| 459 | N-linked (GlcNAc...) asparagine |
|
||
| 478 | N-linked (GlcNAc...) asparagine |
|
G92942VI
G31852PQ
G17023GV
G58053OY
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Mus musculus |
