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Genome polyprotein

Summary

UniProt ID: O39929
Gene ID: 11027168
Organism: Hepatitis C virus ED43

External Links

PubChem: O39929
Re-Glyco: O39929

Annotation

Keyword: 3D-structure Acetylation Activation of host autophagy by virus Apoptosis Capsid protein Clathrin-mediated endocytosis of virus by host Disulfide bond Fusion of virus membrane with host endosomal membrane G1/S host cell cycle checkpoint dysregulation by virus Glycoprotein Helicase Host cell membrane Host cytoplasm Host endoplasmic reticulum Host lipid droplet Host mitochondrion Host nucleus Inhibition of host MAVS by virus Inhibition of host STAT1 by virus Inhibition of host TRAFs by virus Isopeptide bond Magnesium Metal-binding Multifunctional enzyme Oncogene Palmitate Phosphoprotein RNA-binding RNA-directed RNA polymerase Ribonucleoprotein SH3-binding Serine protease Thiol protease Transcription regulation Transmembrane helix Ubl conjugation Viral RNA replication Viral attachment to host cell Viral envelope protein Viral ion channel Viral nucleoprotein Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF GO_REF
virion attachment to host cell	IEA	GO_REF
symbiont-mediated transformation of host cell	IEA	GO_REF
ion transmembrane transport	IEA	GO_REF
monoatomic ion transmembrane transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

protein metabolic process [inference]

proteolysis

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

viral RNA genome replication

protein metabolic process [inference]

proteolysis

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

transmembrane transport [inference]

monoatomic ion transmembrane transport

viral process [inference]

viral genome replication [inference]

viral RNA genome replication

membrane fusion involved in viral entry into host cell [inference]

fusion of virus membrane with host endosome membrane

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host cellular process [inference]

symbiont-mediated transformation of host cell

symbiont-mediated perturbation of host cell cycle progression [inference]

symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint

symbiont-mediated perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host JAK-STAT cascade [inference]

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity [inference]

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity

symbiont-mediated suppression of host TRAF-mediated signal transduction

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

symbiont-mediated suppression of host interferon-mediated signaling pathway [inference]

symbiont-mediated suppression of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host autophagy [inference]

symbiont-mediated activation of host autophagy

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated perturbation of host innate immune response [inference]

symbiont-mediated suppression of host innate immune response [inference]

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

symbiont-mediated suppression of host immune response [inference]

symbiont-mediated suppression of host innate immune response [inference]

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host cellular process [inference]

symbiont-mediated transformation of host cell

symbiont-mediated perturbation of host cell cycle progression [inference]

symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint

symbiont-mediated perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host JAK-STAT cascade [inference]

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity [inference]

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity

symbiont-mediated suppression of host TRAF-mediated signal transduction

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

symbiont-mediated suppression of host interferon-mediated signaling pathway [inference]

symbiont-mediated suppression of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host autophagy [inference]

symbiont-mediated activation of host autophagy

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated perturbation of host innate immune response [inference]

symbiont-mediated suppression of host innate immune response [inference]

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

symbiont-mediated suppression of host immune response [inference]

symbiont-mediated suppression of host innate immune response [inference]

symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway [inference]

symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway [inference]

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

transmembrane transport [inference]

monoatomic ion transmembrane transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
viral nucleocapsid	IEA	GO_REF
viral envelope	IEA	GO_REF GO_REF
host cell plasma membrane	ISS	GO_REF
host cell plasma membrane	IEA	GO_REF
host cell nucleus	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

virion component [inference]

viral nucleocapsid

viral membrane [inference]

viral envelope

virion membrane

cellular anatomical structure [inference]

other organism part [inference]

host cellular component [inference]

host cell part [inference]

host cell membrane [inference]

host intracellular part [inference]

host intracellular organelle [inference]

host intracellular membrane-bounded organelle [inference]

host cell nucleus

host cell cytoplasm part [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
RNA binding	IEA	GO_REF GO_REF
RNA helicase activity	IEA	GO_REF
RNA-directed RNA polymerase activity	IEA	GO_REF GO_REF GO_REF
cysteine-type endopeptidase activity	IEA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

RNA-directed RNA polymerase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity [inference]

RNA helicase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

RNA-directed RNA polymerase activity

structural molecule activity

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

protein domain specific binding [inference]

SH3 domain binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

RNA helicase activity

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRPSWGPNDPRGRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGSVARALAHGVRALEDGINYATGNLPGCSFSIFLLALLSCLTVPASAVNYRNVSGIYHVTNDCPNSSIVYEADHHIMHLPGCVPCVREGNQSRCWVALTPTVAAPYIGAPLESLRSHVDLMVGAATVCSGLYIGDLCGGLFLVGQMFSFRPRRHWTTQDCNCSIYTGHITGHRMAWDMMMNWSPTTTLVLAQVMRIPTTLVDLLSGGHWGVLVGVAYFSMQANWAKVILVLFLFAGVDAETHVSGAAVGRSTAGLANLFSSGSKQNLQLINSNGSWHINRTALNCNDSLNTGFLASLFYTHKFNSSGCSERLACCKSLDSYGQGWGPLGVANISGSSDDRPYCWHYAPRPCGIVPASSVCGPVYCFTPSPVVVGTTDHVGVPTYTWGENETDVFLLNSTRPPHGAWFGCVWMNSTGFTKTCGAPPCEVNTNNGTWHCPTDCFRKHPETTYAKCGSGPWITPRCLIDYPYRLWHFPCTANFSVFNIRTFVGGIEHRMQAACNWTRGEVCGLEHRDRVELSPLLLTTTAWQILPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSAVVSWALKWEYVVLAFLLLADARVSAYLWMMFMVSQVEAALSNLININAASAAGAQGFWYAILFICIVWHVKGRFPAAAAYAACGLWPCFLLLLMLPERAYAYDQEVAGSLGGAIVVMLTILTLSPHYKLWLARGLWWIQYFIARTEAVLHVYIPSFNVRGPRDSVIVLAVLVCPDLVFDITKYLLAILGPLHILQASLLRIPYFVRAQALVKICSLLRGVVYGKYFQMVVLKSRGLTGTYIYDHLTPMSDWPPYGLRDLAVALEPVVFTPMEKKVIVWGADTAACGDIIRGLPVSARLGNEILLGPADTETSKGWRLLAPITAYAQQTRGLFSTIVTSLTGRDTNENCGEVQVLSTATQSFLGTAVNGVMWTVYHGAGAKTISGPKGPVNQMYTNVDQDLVGWPAPPGVRSLAPCTCGSADLYLVTRHADVIPVRRRGDTRGALLSPRPISILKGSSGGPLLCPMGHRAGIFRAAVCTRGVAKAVDFVPVESLETTMRSPVFTDNSTPPAVPQTYQVAHLHAPTGSGKSTKVPAAHAAQGYKVLVLNPSVAATLGFGVYMSKAYGIDPNIRSGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECYSTDSTTILGIGTVLDQAETAGVRLTVLATATPPGSVTTPHSNIEEVALPTTGEIPFYGKAIPLELIKGGRHLIFCHSKKKCDELARQLTSLGLNAVAYYRGLDVSVIPTSGDVVVCATDALMTGFTGDFDSVIDCNTSVIQTVDFSLDPTFSIEITTVPQDAVSRSQRRGRTGRGRLGTYRYVTPGERPSGMFDTAELCECYDAGCAWYELTPAETTTRLKAYFDTPGLPVCQDHLEFWESVFTGLTHIDGHFLSQTKQSGENFPYLVAYQATVSAKVWLAPPSWDTMWKCLIRLKPTLHGPTPLLYRLGSVQNEVVLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLSVGSVVIVGRVVLSGQPAVIPDREVLYQQFDEMEECSKHLPLVEHGLQLAEQFKQKALGLLNFAGKQAQEATPVIQSNFAKLEQFWANDMWNFISGIQYLAGLSTLPGNPAIASLMSFTAAVTSPLTTQQTLLFNILGGWVASQIRDSDASTAFVVSGLAGAAVGSVGLGKILVDILPGYGAGVRGAVVTFKIMSGEMPSTEDLVNLLPAILSPGALVVEVVCPAILRRHVGPGEGAVQWMNRLIAFASRGNHVSPTHYVPESDAARRVTTILSSLTVTSLLRRLHKWINEDCSTPCAESWLWEVWDWVLHVLSDFKTCLKAKFVPLMPGIPLLSWPRGYKGEWRGDGVMHTTCPCGADLAGHIKNGSMRITGPKTCSNTWHGTFPINAYTTGPGVPIPAPNYKFALWRVSAEDYVEVRRVGDFHYVTGVTQDNIKFPCQVPAPELFTEVDGIRIHRHAPKCKPLLRDEVSFSVGLNSFVVGSQLPCEPEPDVAVLTSMLTDPSHITAESARRRLARGSRPSLASSSASQLSPRLLQATCTAPHDSPGTDLLEANLLWGSTATRVETDEKVIILDSFESCVAEQNDDREVSVAAEILRPTKKFPPALPIWARPDYNPPLTETWKQQDYQAPTVHGCALPPAKQPPVPSPRRKRTVQLTESVVSTALAELAAKTFGQSEPSSDRDTDLTTPTETTDSGPIVVDDASDDGSYSSMPPLEGEPGDPDLTSDSWSTVSGSEDVVCCSMSYSWTGALVTPCAAEESKLPISPLSNSLLRHHNMVYATTTRSAVTRQKKVTFDRLQVVDSTYNEVLKEIKARASRVKPRLLTTEEACDLTPPHSARSKFGYGKKDVRSHSRKAINHISSVWKDLLDDNNTPIPTTIMAKNEVFAVNPAKGGRKPARLIVYPDLGSRVCEKRALHDVIKKTALAVMGAAYGFQYSPAQRVEFLLTAWKSKNDPMGFSYDTRCFDSTVTEKDIRVEEEVYQCCDLEPEARKVITALTDRLYVGGPMHNSKGDLCGYRRCRATGVYTTSFGNTLTCYLKATAAIRAAALRDCTMLVCGDDLVVIAESDGVEEDNRALRAFTEAMTRYSAPPGDAPQPAYDLELITSCSSNVSVAHDVTGKKVYYLTRDPETPLARAVWETVRHTPVNSWLGNIIVYAPTIWVRMILMTHFFSILQSQEALEKALDFDMYGVTYSITPLDLPAIIQRLHGLSAFTLHGYSPHELNRVAGALRKLGVPPLRAWRHRARAVRAKLIAQGGRAKICGIYLFNWAVKTKLKLTPLPAAAKLDLSGWFTVGAGGGDIYHSMSHARPRYLLLCLLILTVGVGIFLLPAR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	Source
196	N-linked (GlcNAc...) asparagine; by host	UniProt
209	N-linked (GlcNAc...) asparagine; by host	UniProt
234	N-linked (GlcNAc...) asparagine; by host	UniProt
305	N-linked (GlcNAc...) asparagine; by host	UniProt
417	N-linked (GlcNAc...) (high mannose) asparagine; by host	UniProt
423	N-linked (GlcNAc...) (high mannose) asparagine; by host	UniProt
430	N-linked (GlcNAc...) (high mannose) asparagine; by host	UniProt
448	N-linked (GlcNAc...) asparagine; by host	UniProt
476	N-linked (GlcNAc...) asparagine; by host	UniProt
533	N-linked (GlcNAc...) asparagine; by host	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements