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Dorsal-ventral patterning tolloid-like protein 1

Summary

UniProt ID: O57460
Gene Symbol: tll1 mfn tld tolloid
Gene ID: 474335
Organism: Danio rerio (zebrafish)

External Links

Re-Glyco: O57460

Annotation

Keyword: Calcium Developmental protein Disulfide bond EGF-like domain Glycoprotein Metal-binding Metalloprotease Reference proteome Repeat Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
blood vessel development	IMP	PMID
mesoderm formation	IMP	PMID
endothelial cell development	IMP	PMID
proteolysis	IDA	PMID PMID
proteolysis	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

determination of ventral identity

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

caudal fin morphogenesis [inference]

embryonic caudal fin morphogenesis

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

animal gross anatomical part developmental process [inference]

blood vessel development

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF
calcium ion binding	IEA	GO_REF
peptidase activity	IDA	PMID
metallopeptidase activity	IDA	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDYLYSALTSKMNWIALLLAGLTFCCKVSVHSCLDYDDSYDYYEEEKTETIDYKDPCKAAVFWGDIALDDEDLKMFHIDGTIDLKQQTHGRQGHTSGGLGEHVPTKKRGSLYLLLDRIRRLGFESWPVNSSKDVSSIKTGIRRVNSARNVKSRVPRAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDISQAKKLYRCPACGETLQDSVGNFSSPGYPNGYPSYTHCVWRISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQVFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAANFFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEVCKYDYVEVRSGLSSDSKLHGKYCGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIEQHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTECGGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIELYDGYDTGAHKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRYTSTKFQEALHTRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
129	N-linked (GlcNAc...) asparagine	UniProt
178	N-linked (GlcNAc...) asparagine	UniProt
368	N-linked (GlcNAc...) asparagine	UniProt
399	N-linked (GlcNAc...) asparagine	UniProt
635	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Collagen biosynthesis and modifying enzymes	Danio rerio
Crosslinking of collagen fibrils	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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International Collaboration

Acknowledgements