GlyCosmos Portal

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Cubilin

Summary

UniProt ID

O60494

Gene Symbol

CUBN
IFCR

Organism

Homo sapiens (human)

External Links

GlyConnect

2033

GlyGen

O60494

PubChem

O60494

The Human Metabolome Database

HMDBP02626

RaftProt

O60494

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cholesterol metabolism
Cleavage on pair of basic residues
Coated pit
Cobalamin
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Lysosome
Metal-binding
Phosphoprotein
Protein transport
Receptor
Reference proteome
Repeat
Signal

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
tissue homeostasis
cobalamin metabolic process
response to bacterium
establishment of localization in cell
receptor-mediated endocytosis
cholesterol metabolic process
lipoprotein transport
cobalamin transport

Displaying entries **1 - 10** of 16 in total

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GO Term
endosome
endoplasmic reticulum
Golgi apparatus
cytosol
apical plasma membrane
endocytic vesicle
plasma membrane
membrane
receptor complex
extrinsic component of external side of plasma membrane

Displaying **all 5** entries
GO Term
cobalamin binding
cargo receptor activity
protein homodimerization activity
calcium ion binding
signaling receptor activity

Annotation information from UniProt.

Sequence

MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 52 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
105	N-linked (GlcNAc...) asparagine		G94665LC G30221QT G81637OR G65414LI G50856PC G99679NM G82443XX G95046LV G56518TU G01160VV G60967DT G80669SJ G39471UU G05962QB G30740WO G12341GU G55132BD G37818NZ G69521XL G03644CB G06247RL G35541EV G93718GY G85677PP G13131HA G49755GI G75568BH G80075MS G57776ZS G16125XL G29545VG G44753VC G68490OW G99668VU G77669RF G60834IK G86880BF G27947YN G28622IK G90382BL G30970QQ G80479JV G85282JO G20528HD G87123QX G79666IR G92135MA G98611JV G43734MM G34989PA G02528FI G45395BF G59324HL G07246CJ G85554PZ G10819WX G40926MX G14972EH G43223CG G00273SJ G08918WF G00912UN G49906RN G27915IV G87389XI G23505EP G70441OD G87661QW G83646BJ G04657PL G27058EU G43769HG G83460ZZ G37509XX G70223PD G60033FS G41071NU G07755XJ G86182NS G72747WU G70619PT G59626AS G80920RR G47702MW G63041LO G01485JJ G65184UU G42124LM G90659AW G62765YT G72790NZ G95177YH G05049YU G31852PQ G23719VF G11314AS G41247ZX G02815KT G37995HC	UniProt GlyGen
428	N-linked (GlcNAc...) asparagine			UniProt GlyGen
482	N-linked (GlcNAc...) asparagine		G80479JV G85282JO G45395BF G07246CJ G14972EH G43223CG G49906RN G27915IV G70441OD G87661QW G83646BJ G15664MX G46691LC G27126ED G04657PL G27058EU G24528MX G83460ZZ G70223PD G60033FS G41071NU G07755XJ G86182NS G72747WU G70619PT G59626AS G46503DX G25079LO G80920RR G73968GN G65184UU G42124LM G90659AW G62765YT G72790NZ G95177YH G10486CT G05049YU G95865ZB G31852PQ G49955PK G72787SB G23719VF G11314AS G35029YA G36379GD G02815KT G92275SC G37995HC	UniProt GlyGen
688			G29068FM	GlyGen
711	N-linked (GlcNAc...) asparagine		G33416PL G07246CJ G40926MX G49906RN G27915IV G70441OD G43769HG G83460ZZ G60033FS G41071NU G72747WU G59626AS G46503DX G25079LO G80920RR G65184UU G42124LM G02886BB G90659AW G62765YT G72790NZ G10486CT G28541PG G31852PQ G49955PK G72787SB G23719VF G39446WN G41247ZX G57776ZU G02815KT G57317CE	UniProt GlyGen
749	N-linked (GlcNAc...) asparagine			UniProt GlyGen
781	N-linked (GlcNAc...) asparagine		G12261QD G93718GY G13131HA G80075MS G57776ZS G16125XL G29545VG G68490OW G60834IK G86880BF G27947YN G28622IK G90382BL G30970QQ G80479JV G85282JO G20528HD G87123QX G79666IR G92135MA G98611JV G43734MM G02528FI G43669FQ G45395BF G07246CJ G85554PZ G10819WX G40926MX G14972EH G43223CG G00273SJ G08918WF G00912UN G49906RN G27915IV G87389XI G23505EP G70441OD G87661QW G83646BJ G76295SF G15664MX G04657PL G27058EU G43769HG G83460ZZ G37509XX G70223PD G60033FS G41071NU G07755XJ G86182NS G72747WU G70619PT G59626AS G08290VR G46503DX G01650EU G25079LO G80920RR G01485JJ G65184UU G42124LM G02886BB G90659AW G77547TA G45504EY G59924QI G37399XV G83633GK G62765YT G47644PP G72790NZ G95177YH G10486CT G05049YU G28541PG G18647XP G85269DF G95865ZB G31852PQ G49955PK G72787SB G23719VF G39446WN G11314AS G41247ZX G35029YA G57776ZU G36379GD G02815KT G92050GC G92275SC	UniProt GlyGen
857	N-linked (GlcNAc...) asparagine			UniProt GlyGen
957	N-linked (GlcNAc...) asparagine			UniProt GlyGen
984	N-linked (GlcNAc...) asparagine	20237569		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Defective AMN causes MGA1	Homo sapiens
Defective CUBN causes MGA1	Homo sapiens
HDL clearance	Homo sapiens
Uptake of dietary cobalamins into enterocytes	Homo sapiens
Vitamin D (calciferol) metabolism	Homo sapiens

Human Protein Atlas

ENSG00000107611

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements