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MIRAGE
Toll-like receptor 2

Summary
UniProt ID
O60603
Gene Symbol
  • TIL4
  • TLR2
Gene ID
7097
Organism
Homo sapiens (human)
GlyConnect
GlyGen
O60603
PubChem
O60603
The Human Metabolome Database
HMDBP12412
Re-Glyco
O60603
Annotation
Keyword
  • 3D-structure
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Inflammatory response
  • Innate immunity
  • Isopeptide bond
  • Leucine-rich repeat
  • NAD
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Gene Ontology (GO)
Displaying entries 1 - 10 of 12 in total
GO Term
cytoplasm
plasma membrane
secretory granule membrane
cell projection
receptor complex
cell body
Golgi apparatus
cell surface
membrane raft
phagocytic vesicle membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
114 N-linked (GlcNAc...) asparagine
199 N-linked (GlcNAc...) asparagine
414 N-linked (GlcNAc...) asparagine
442 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 12 in total
Pathway Name Organism
Beta defensins Homo sapiens
ER-Phagosome pathway Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
Modulation by Mtb of host immune system Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
Neutrophil degranulation Homo sapiens
RSV-host interactions Homo sapiens
Regulation of TLR by endogenous ligand Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Disease
Displaying entries 1 - 10 of 23 in total
DO ID Disease Name Source
DOID:1612 breast cancer
DOID:0080176 meningococcal meningitis
DOID:0080784 urinary tract infection
DOID:1024 leprosy
DOID:10283 prostate cancer
DOID:11054 urinary bladder cancer
DOID:12306 vitiligo
DOID:13241 Behcet's disease
DOID:1407 anterior uveitis
DOID:1495 cystic echinococcosis
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025