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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Low-density lipoprotein receptor-related protein 5
Summary
- UniProt ID
- O75197
- Gene Symbol
-
- LRP5
- LR3
- LRP7
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- O75197
- PubChem
- O75197
- The Human Metabolome Database
- HMDBP07786
- The O-GlcNAc Database
- O75197
Annotation
- Keyword
-
- Developmental protein
- Disease variant
- Disulfide bond
- EGF-like domain
- Endocytosis
- Endoplasmic reticulum
- Glycoprotein
- Osteogenesis imperfecta
- Osteopetrosis
- Osteoporosis
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Wnt signaling pathway
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum |
| plasma membrane |
| receptor complex |
| Wnt signalosome |
| Wnt-Frizzled-LRP5/6 complex |
| GO Term |
|---|
| Wnt-protein binding |
| coreceptor activity |
| Wnt receptor activity |
Sequence
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 93 | N-linked (GlcNAc...) asparagine | |||
| 138 | N-linked (GlcNAc...) asparagine | |||
| 446 | N-linked (GlcNAc...) asparagine |
|
||
| 499 | N-linked (GlcNAc...) asparagine |
|
||
| 705 | N-linked (GlcNAc...) asparagine |
|
||
| 878 | N-linked (GlcNAc...) asparagine |
|
||
| 940 |
|
|||
| 1122 |
|
|||
| 1578 |
|
|
G80920RR
G70101JE
G83460ZZ
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | Homo sapiens |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | Homo sapiens |
| Regulation of FZD by ubiquitination | Homo sapiens |
| Signaling by LRP5 mutants | Homo sapiens |
| Signaling by RNF43 mutants | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
