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MIRAGE
Low-density lipoprotein receptor-related protein 6
Summary
- UniProt ID
- O75581
- Gene Symbol
-
- LRP6
- Gene ID
- 4040
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Developmental protein
- Disease variant
- Disulfide bond
- EGF-like domain
- Endocytosis
- Endoplasmic reticulum
- Glycoprotein
- Isopeptide bond
- Palmitate
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Ubl conjugation
- Wnt signaling pathway
- Gene Ontology (GO)
| GO Term |
|---|
| early endosome membrane |
| membrane raft |
| Wnt signalosome |
| Wnt-Frizzled-LRP5/6 complex |
| extracellular region |
| plasma membrane |
| cytoplasmic vesicle |
| neuronal cell body |
| synapse |
| endoplasmic reticulum |
Sequence
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 42 | N-linked (GlcNAc...) asparagine |
|
||
| 81 | N-linked (GlcNAc...) asparagine |
|
||
| 281 | N-linked (GlcNAc...) asparagine | |||
| 433 | N-linked (GlcNAc...) asparagine |
|
||
| 486 | N-linked (GlcNAc...) asparagine |
|
||
| 692 | N-linked (GlcNAc...) asparagine |
|
||
| 859 | N-linked (GlcNAc...) asparagine |
|
||
| 865 | N-linked (GlcNAc...) asparagine |
|
||
| 926 | N-linked (GlcNAc...) asparagine |
|
||
| 1039 | N-linked (GlcNAc...) asparagine |
|
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | Homo sapiens |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | Homo sapiens |
| Regulation of FZD by ubiquitination | Homo sapiens |
| Signaling by RNF43 mutants | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050591 | tooth agenesis |
