GlyCosmos Portal

Submissions

Histone-lysine N-methyltransferase SETDB1

Summary

UniProt ID

O88974

Gene Symbol

Setdb1
Eset
Kiaa0067

Organism

Mus musculus (house mouse)

External Links

GlyGen: O88974
PubChem: O88974
The O-GlcNAc Database: O88974
O-GlcNAcAtlas: O88974
Re-Glyco: O88974

Annotation

Keyword

Alternative splicing
Chromatin regulator
Chromosome
Coiled coil
Isopeptide bond
Metal-binding
Methylation
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor
S-adenosyl-L-methionine
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
nucleus
chromosome
cytoplasm

Displaying **all 8** entries
GO Term
negative regulation of gene expression
bone development
inner cell mass cell proliferation
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription by RNA polymerase II
methylation
heterochromatin organization
positive regulation of DNA methylation-dependent heterochromatin formation

Displaying **all 7** entries
GO Term
chromatin binding
zinc ion binding
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
DNA binding
promoter-specific chromatin binding
histone H3K9 methyltransferase activity

Annotation information from UniProt.

Sequence

MSSLPGCMSLAAAPAAADSAEIAELQQAVVEELGISMEELRQYIDEELEKMDCIQQRKKQLAELETWVLQKESEVAYVDRLFDDASREVTNCESLVKDFYSKLGLQYHDSSSEDEASRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIEEYITAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQYTQDLTGTGIQFKPMEPLQPIAPPAPLPIPPLSPQAADTDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSSTLSENVSAGKLGINQTYRSPLASVTSTPASAAPPVPPVPPGPPTPPGPPAPPGPLAPPAFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQVNPNSGYQYKRLEECLPTGVYECNKRCNCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDVPTSSDSSGVDMKDQEDGNSGSEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENELSEMTSKDSRPPDLGPPHVPIPSSVSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDGRAGGGRGEAERASTSGLSFKDEGDNKQPKKEDPENRNKMPVVTEGSQNHGHNPPMKSEGLRRPASKMSVLQSQRVVTSTQSNPDDILTLSSSTESEGESGTSRKPTAGHTSATAVDSDDIQTISSGSDGDDFEDKKNLSGPTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites