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Alpha-actinin-3

Summary

UniProt ID

O88990

Gene Symbol

Actn3

Gene ID

11474

Organism

Mus musculus (house mouse)

External Links

GlyGen: O88990
The O-GlcNAc Database: O88990
O-GlcNAcAtlas: O88990
Re-Glyco: O88990

Annotation

Keyword

Acetylation
Actin-binding
Calcium
Metal-binding
Reference proteome
Repeat

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
sarcomere
Z disc
brush border
focal adhesion
striated muscle thin filament

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 19 in total

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GO Term
response to denervation involved in regulation of muscle adaptation
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of skeletal muscle fiber development
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of oxidative phosphorylation
negative regulation of relaxation of muscle
regulation of aerobic respiration
positive regulation of glucose catabolic process to lactate via pyruvate
negative regulation of cold-induced thermogenesis
focal adhesion assembly

Displaying **all 5** entries
GO Term
protein-macromolecule adaptor activity
identical protein binding
transmembrane transporter binding
actin filament binding
calcium ion binding

Annotation information from UniProt.

Sequence

MMMVMQPEGLGAGEGPFSGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites