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Caspase-8

Summary

UniProt ID

O89110

Gene Symbol

Casp8

Organism

Mus musculus (house mouse)

External Links

GlyGen: O89110
PubChem: O89110
The O-GlcNAc Database: O89110

Annotation

Keyword

Acetylation
Apoptosis
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
Thiol protease
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 26 in total

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GO Term
apoptotic process
heart development
protein processing
macrophage differentiation
regulation of innate immune response
cardiac muscle tissue development
proteolysis involved in protein catabolic process
apoptotic signaling pathway
execution phase of apoptosis
positive regulation of apoptotic process

Displaying **all 10** entries
GO Term
nucleus
cytoplasm
plasma membrane
protein-containing complex
cell body
Noc1p-Noc2p complex
death-inducing signaling complex
CD95 death-inducing signaling complex
mitochondrion
ripoptosome

Displaying **all 10** entries
GO Term
cysteine-type endopeptidase activity involved in apoptotic process
endopeptidase activity
cysteine-type endopeptidase activity
death receptor binding
tumor necrosis factor receptor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
death effector domain binding
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
peptidase activity
protein-containing complex binding

Annotation information from UniProt.

Sequence

MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 16 in total

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Pathway Name	Organism
Activation of BID and translocation to mitochondria	Mus musculus
Apoptotic cleavage of cellular proteins	Mus musculus
Apoptotic execution phase	Mus musculus
CASP8 activity is inhibited	Mus musculus
CLEC7A/inflammasome pathway	Mus musculus
Caspase-mediated cleavage of cytoskeletal proteins	Mus musculus
Dimerization of procaspase-8	Mus musculus
FasL/ CD95L signaling	Mus musculus
Ligand-dependent caspase activation	Mus musculus
NOD1/2 Signaling Pathway	Mus musculus