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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Methyl-CpG-binding domain protein 4
Summary
- UniProt ID
- O95243
- Gene Symbol
-
- MBD4
- MED1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- DNA repair
- DNA-binding
- Disease variant
- Hydrolase
- Nucleus
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| response to estradiol |
| depyrimidination |
| DNA repair |
| GO Term |
|---|
| nucleus |
| nuclear speck |
| nucleoplasm |
| GO Term |
|---|
| DNA binding |
| satellite DNA binding |
| DNA endonuclease activity |
| DNA N-glycosylase activity |
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity |
Sequence
MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSECNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRSKSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRTRSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKGIPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETLSVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGTKVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 206 |
|
|||
|
|
G62765YT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cleavage of the damaged pyrimidine | Homo sapiens |
| Displacement of DNA glycosylase by APEX1 | Homo sapiens |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0080195 | Marinesco-Sjogren syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:1019 | osteomyelitis | |
| DOID:10534 | stomach cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11266 | Hantavirus hemorrhagic fever with renal syndrome | |
| DOID:11661 | blue color blindness | |
| DOID:12849 | autistic disorder | |
| DOID:1324 | lung cancer |
