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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Phosphoglycerate kinase 1
Summary
- UniProt ID
- P00558
- Gene Symbol
-
- PGK1
- PGKA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycolysis
- Hereditary hemolytic anemia
- Hydroxylation
- Kinase
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| membrane raft |
| extracellular space |
| membrane |
| extracellular exosome |
| GO Term |
|---|
| phosphoglycerate kinase activity |
| ADP binding |
| protein-disulfide reductase (NAD(P)) activity |
| ATP binding |
Sequence
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 35 |
|
|||
| 46 |
|
|||
| 174 |
|
|||
| 175 |
|
|||
| 255 |
|
|||
| 415 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Gluconeogenesis | Homo sapiens |
| Glycolysis | Homo sapiens |
| Manipulation of host energy metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0050819 | obsolete Matthew-Wood syndrome | |
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0060013 | X-linked severe combined immunodeficiency | |
| DOID:0060600 | obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum | |
| DOID:0060613 | X-linked cleft palate with or without ankyloglossia | |
| DOID:0060843 | hereditary neuropathy with liability to pressure palsies | |
| DOID:0060891 | Parkinson's disease 19A |
