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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Coagulation factor XII
Summary
- UniProt ID
- P00748
- Gene Symbol
-
- F12
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011282
- GlyConnect
- GlyGen
- P00748
- PubChem
- P00748
- The Human Metabolome Database
- HMDBP02054
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Fibrinolysis
- Glycoprotein
- Kringle
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Factor XII activation |
| positive regulation of plasminogen activation |
| response to misfolded protein |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| collagen-containing extracellular matrix |
| extracellular exosome |
| rough endoplasmic reticulum |
| GO Term |
|---|
| misfolded protein binding |
| serine-type endopeptidase activity |
| calcium ion binding |
Sequence
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 329 | O-linked (GalNAc...) threonine |
|
||
| 331 |
|
|||
| 335 |
|
|||
| 337 | O-linked (GalNAc...) threonine | |||
| 433 | N-linked (GlcNAc...) asparagine |
G57321FI
G43417UB
G29068FM
G35107SO
G10019LZ
G62461SM
G57888GL
G06247RL
G04854VP
G94470IW
G22310AV
G45395BF
G08918WF
G00912UN
G48414YA
G92551JA
G06356OH
G59626AS
G10486CT
G95865ZB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective SERPING1 causes hereditary angioedema | Homo sapiens |
| Defective factor XII causes hereditary angioedema | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
