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MIRAGE
Transforming growth factor beta-1 proprotein

Summary
UniProt ID
P01137
Gene Symbol
  • TGFB
  • TGFB1
Gene ID
7040
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011299
GlyConnect
GlyGen
P01137
PubChem
P01137
The Human Metabolome Database
HMDBP14566
RaftProt
P01137
Re-Glyco
P01137
Annotation
Keyword
  • 3D-structure
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Growth factor
  • Mitogen
  • Reference proteome
  • Signal
Gene Ontology (GO)
Displaying entries 1 - 10 of 13 in total
GO Term
extracellular region
extracellular space
nucleus
cytoplasm
plasma membrane
axon
extracellular matrix
neuronal cell body
collagen-containing extracellular matrix
Golgi lumen
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
82 N-linked (GlcNAc...) asparagine
136 N-linked (GlcNAc...) asparagine
176 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 11 - 20 of 21 in total
Pathway Name Organism
SMAD2/3 Phosphorylation Motif Mutants in Cancer Homo sapiens
Syndecan interactions Homo sapiens
TGF-beta receptor signaling activates SMADs Homo sapiens
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Homo sapiens
TGFBR1 KD Mutants in Cancer Homo sapiens
TGFBR1 LBD Mutants in Cancer Homo sapiens
TGFBR2 Kinase Domain Mutants in Cancer Homo sapiens
TGFBR2 MSI Frameshift Mutants in Cancer Homo sapiens
TGFBR3 regulates TGF-beta signaling Homo sapiens
Transcriptional regulation of white adipocyte differentiation Homo sapiens
Disease
Displaying entries 1 - 10 of 25 in total
DO ID Disease Name Source
DOID:0050589 inflammatory bowel disease
DOID:10322 berylliosis
DOID:12134 factor VIII deficiency
DOID:12449 aplastic anemia
DOID:13141 uveitis
DOID:13241 Behcet's disease
DOID:13406 pulmonary sarcoidosis
DOID:13922 eosinophilic esophagitis
DOID:1485 cystic fibrosis
DOID:1612 breast cancer
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025