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Beta-nerve growth factor

Summary

UniProt ID

P01139

Gene Symbol

Ngf
Ngfb

Gene ID

18049

Organism

Mus musculus (house mouse)

External Links

PubChem: P01139
The Human Metabolome Database: HMDBP13922
Re-Glyco: P01139

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
Growth factor
Lipid-binding
Metalloprotease inhibitor
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum lumen
endosome lumen

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of neuron projection development
neuron projection development
negative regulation of neuron apoptotic process
positive regulation of axon extension
axon extension
regulation of release of sequestered calcium ion into cytosol
neuron apoptotic process
positive regulation of neuron maturation
positive regulation of protein ubiquitination
nerve growth factor signaling pathway

Displaying **all 4** entries
GO Term
growth factor activity
metalloendopeptidase inhibitor activity
lipid binding
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPTAPIAARVTGQTRNITVDPRLFKKRRLHSPRVLFSTQPPPTSSDTLDLDFQAHGTIPFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATRRG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
69	N-linked (GlcNAc...) asparagine			UniProt
114	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 12 in total

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Pathway Name	Organism
ARMS-mediated activation	Mus musculus
Axonal growth stimulation	Mus musculus
Frs2-mediated activation	Mus musculus
NADE modulates death signalling	Mus musculus
NF-kB is activated and signals survival	Mus musculus
NFG and proNGF binds to p75NTR	Mus musculus
NGF processing	Mus musculus
NRIF signals cell death from the nucleus	Mus musculus
PI3K/AKT activation	Mus musculus
Retrograde neurotrophin signalling	Mus musculus