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Pro-opiomelanocortin

Summary

UniProt ID

P01190

Gene Symbol

POMC

Gene ID

281416

Organism

Bos taurus (domestic cattle)

External Links

GlyConnect

Corticotropin - lipotropin, npp peptide

PubChem

P01190

Re-Glyco

P01190

Annotation

Keyword

Acetylation
Amidation
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Endorphin
Glycoprotein
Hormone
Phosphoprotein
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Sulfation

Gene Ontology (GO)

Displaying **all 2** entries
GO Term
secretory granule
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 15 in total

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2

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GO Term
generation of precursor metabolites and energy
cell-cell signaling
regulation of blood pressure
regulation of appetite
glucose homeostasis
regulation of glycogen metabolic process
positive regulation of transcription by RNA polymerase II
cellular pigmentation
positive regulation of oxytocin production
response to melanocyte-stimulating hormone

Displaying **all 5** entries
GO Term
G protein-coupled receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
type 1 melanocortin receptor binding
hormone activity

Annotation information from UniProt.

Sequence

MPRLCSSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSSGVGGAAQKREEEVAVGEGPGPRGDDAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
71	O-linked (GalNAc...) threonine	4030947	G97420WF G05428SU G63628AV G64973KT G00031MO G29931IJ	UniProt GlyConnect
91	N-linked (GlcNAc...) asparagine	4030947	G15861GO G17739US G70418MS G73029YR G83568RU G44215PV G54584SU G34861PV G49278EO G03382KH G22632KM G23863VK G82701UX G09684AX G37246US G10256JP G55184VW G46687AB G86759QR G75155SG G97483RC G41440AQ G49874UX	UniProt GlyConnect

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Androgen biosynthesis	Bos taurus
Endogenous sterols	Bos taurus
G alpha (i) signalling events	Bos taurus
G alpha (s) signalling events	Bos taurus
G-protein activation	Bos taurus
Glucocorticoid biosynthesis	Bos taurus
Opioid Signalling	Bos taurus
Peptide hormone biosynthesis	Bos taurus
Peptide ligand-binding receptors	Bos taurus