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Interleukin-2 receptor subunit alpha

Summary

UniProt ID

P01589

Gene Symbol

IL2RA

Organism

Homo sapiens (human)

External Links

GlyGen: P01589
PubChem: P01589
The O-GlcNAc Database: P01589

Annotation

Keyword

3D-structure
Diabetes mellitus
Disease variant
Disulfide bond
Glycoprotein
Immunity
Receptor
Reference proteome
Repeat
Signal
Sushi
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 16 in total

1

2

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GO Term
inflammatory response to antigenic stimulus
Notch signaling pathway
interleukin-2-mediated signaling pathway
activation-induced cell death of T cells
positive regulation of activated T cell proliferation
activated T cell proliferation
regulation of T cell tolerance induction
apoptotic process
inflammatory response
immune response

Displaying **all 3** entries
GO Term
plasma membrane
interleukin-2 receptor complex
external side of plasma membrane

Displaying **all 2** entries
GO Term
interleukin-2 receptor activity
interleukin-2 binding

Annotation information from UniProt.

Sequence

MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
60			G49108TO	GlyGen The O-GlcNAc Database
62			G49108TO	GlyGen The O-GlcNAc Database
70	N-linked (GlcNAc...) asparagine	3134887	G23505EP G25079LO	UniProt GlyGen
89	N-linked (GlcNAc...) asparagine	3134887		UniProt GlyGen
218	O-linked (GalNAc...) threonine	3134887		UniProt GlyGen
224	O-linked (GalNAc...) threonine	3134887		UniProt GlyGen
229	O-linked (GalNAc...) threonine	3134887		UniProt GlyGen
237	O-linked (GalNAc...) threonine	3134887		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin receptor SHC signaling	Homo sapiens
Interleukin-2 signaling	Homo sapiens
RAF/MAP kinase cascade	Homo sapiens
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Homo sapiens

Human Protein Atlas

ENSG00000134460

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements