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T-cell surface glycoprotein CD4

Summary

UniProt ID

P01730

Gene Symbol

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P01730

PubChem

P01730

Annotation

Keyword

3D-structure
Adaptive immunity
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **11 - 20** of 32 in total

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GO Term
T cell activation
T cell selection
calcium-mediated signaling
positive regulation of interleukin-2 production
positive regulation of kinase activity
positive regulation of monocyte differentiation
positive regulation of protein kinase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
regulation of T cell activation

Displaying **all 8** entries
GO Term
plasma membrane
T cell receptor complex
clathrin-coated endocytic vesicle membrane
membrane raft
endoplasmic reticulum membrane
early endosome
endoplasmic reticulum lumen
external side of plasma membrane

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GO Term
transmembrane signaling receptor activity
lipid binding
enzyme binding
signaling receptor activity
protein kinase binding
MHC class II protein complex binding
protein tyrosine kinase binding
identical protein binding
protein homodimerization activity
virus receptor activity

Annotation information from UniProt.

Sequence

MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
98				GlyGen
296	N-linked (GlcNAc...) asparagine	19159218 2001369 2592374	G18188WJ G17689DH G22310AV G64132UH G20966IA G48414YA G77252PU G45498YC G05950HG G30460NZ G53752TA G84452RH G37166HP G38756OC G06356OH G07995VK G45560HM G57413FT G65890UA G35599NO G23863VK G27561QX G78059CC G53962WT G36191CD G50045TK G53450AF G87633UQ G20779SK G52622SW G03860PZ G44276EF	UniProt GlyGen GlyConnect
325	N-linked (GlcNAc...) asparagine	2001369 2592374	G18188WJ G17689DH G22310AV G45395BF G64132UH G20966IA G48414YA G77252PU G45498YC G05950HG G30460NZ G53752TA G84452RH G10773YW G37166HP G38756OC G06356OH G07995VK G45560HM G57413FT G01650EU G23294PN G65890UA G34730YF G35599NO G23863VK G27561QX G78059CC G37399XV G53962WT G82463GQ G36191CD G50045TK G53450AF G87633UQ G31852PQ G20779SK G52622SW G03860PZ G44276EF	UniProt GlyGen GlyConnect
			G18188WJ G47518TP G22310AV G64132UH G20966IA G48414YA G45498YC G72797UR G05950HG G84452RH G20425TQ G38756OC G06356OH G57413FT G23863VK G27561QX G64527OM G88433PA G50045TK G53450AF G46687AB G87633UQ G05724UK G63923YN G20779SK G81295CK G29880MM G52622SW G39188ZX G45864TJ G03860PZ G23453IV G89878AA G94854LT G06110VR G44276EF G37738XF G60145BJ	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Alpha-defensins	Homo sapiens
Binding and entry of HIV virion	Homo sapiens
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
Downstream TCR signaling	Homo sapiens
Generation of second messenger molecules	Homo sapiens
Nef Mediated CD4 Down-regulation	Homo sapiens
Other interleukin signaling	Homo sapiens
PD-1 signaling	Homo sapiens
Phosphorylation of CD3 and TCR zeta chains	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

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Annotation

International Collaboration

Acknowledgements