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Apolipoprotein A-I

Summary

UniProt ID

P02647

Gene Symbol

APOA1

Organism

Homo sapiens (human)

External Links

GlyGen: P02647
PubChem: P02647
The Human Metabolome Database: HMDBP01620
RaftProt: P02647

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Atherosclerosis
Cholesterol metabolism
Direct protein sequencing
Disease variant
Glycation
HDL
Lipid transport
Neuropathy
Oxidation
Palmitate
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

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GO Term
regulation of protein phosphorylation
endothelial cell proliferation
negative regulation of cytokine production involved in immune response
G protein-coupled receptor signaling pathway
glucocorticoid metabolic process
negative regulation of inflammatory response
negative regulation of response to cytokine stimulus
adrenal gland development
negative regulation of interleukin-1 beta production
lipoprotein biosynthetic process

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GO Term
cytosol
early endosome
endoplasmic reticulum lumen
very-low-density lipoprotein particle
extracellular region
extracellular space
plasma membrane
endocytic vesicle
cytoplasmic vesicle
collagen-containing extracellular matrix

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GO Term
cholesterol transfer activity
identical protein binding
protein homodimerization activity
chemorepellent activity
amyloid-beta binding
phospholipid binding
high-density lipoprotein particle binding
apolipoprotein receptor binding
apolipoprotein A-I receptor binding
high-density lipoprotein particle receptor binding

Annotation information from UniProt.

Sequence

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
220			G57321FI	GlyGen
221			G57321FI	GlyGen
228			G57321FI	GlyGen
263	N-linked (Glc) (glycation) lysine	8261628		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
ABC transporters in lipid homeostasis	Homo sapiens
Amyloid fiber formation	Homo sapiens
Chylomicron assembly	Homo sapiens
Chylomicron remodeling	Homo sapiens
Defective ABCA1 causes TGD	Homo sapiens
HDL assembly	Homo sapiens
HDL clearance	Homo sapiens
HDL remodeling	Homo sapiens
Heme signaling	Homo sapiens
PPARA activates gene expression	Homo sapiens