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Phosphatidylcholine-sterol acyltransferase

Summary

UniProt ID

P04180

Gene Symbol

LCAT

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011357

GlyConnect

GlyGen

P04180

PubChem

P04180

SwissLipids

SLP:000000660

The Human Metabolome Database

HMDBP00069

Annotation

Keyword

3D-structure
Acyltransferase
Cholesterol metabolism
Corneal dystrophy
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
reverse cholesterol transport
phosphatidylcholine metabolic process
lipid metabolic process
regulation of high-density lipoprotein particle assembly
phospholipid metabolic process
phosphatidylcholine biosynthetic process
cholesterol metabolic process
cholesterol transport
very-low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
extracellular exosome
high-density lipoprotein particle

Displaying **all 5** entries
GO Term
1-alkyl-2-acetylglycerophosphocholine esterase activity
phosphatidylcholine-sterol O-acyltransferase activity
apolipoprotein A-I binding
platelet-activating factor acetyltransferase activity
sterol esterase activity

Annotation information from UniProt.

Sequence

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
44	N-linked (GlcNAc...) (complex) asparagine	16335952 7613477	G33791AF G06247RL G04854VP G63041LO	GlycoProtDB UniProt GlyGen GlyConnect
108	N-linked (GlcNAc...) (complex) asparagine	26195816 7613477		UniProt GlyGen
296	N-linked (GlcNAc...) (complex) asparagine	16335952 26195816 7613477	G12341GU G70232NH G06247RL G27947YN G81263BG G22310AV G00273SJ G08918WF G00912UN G48414YA G66760KM G06356OH	GlycoProtDB UniProt GlyGen GlyConnect
408	N-linked (GlcNAc...) (complex) asparagine	26195816 7613477		UniProt GlyGen
424			G57321FI	GlyGen
431	O-linked (GalNAc...) threonine	7613477		UniProt GlyGen
433	O-linked (GalNAc...) serine	7613477		UniProt GlyGen
			G63889NK G90093AU G72797UR G74286KY G86357DX G20425TQ G22388FD G29857RC G23863VK G78059CC G36191CD G50045TK	GlyGen GlyConnect