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HLA class II histocompatibility antigen gamma chain

Summary

UniProt ID

P04233

Gene Symbol

CD74
DHLAG

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011361

GlyConnect

GlyGen

P04233

PubChem

P04233

The O-GlcNAc Database

P04233

RaftProt

P04233

O-GlcNAcAtlas

P04233

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative initiation
Alternative splicing
Cell membrane
Chaperone
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

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GO Term
positive regulation of DNA-templated transcription
protein stabilization
positive regulation of cytokine-mediated signaling pathway
T cell activation involved in immune response
negative regulation of peptide secretion
positive regulation of type 2 immune response
intracellular protein transport
positive regulation of gene expression
immunoglobulin mediated immune response
antigen processing and presentation

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GO Term
protein-containing complex
MHC class II protein complex
endocytic vesicle membrane
clathrin-coated endocytic vesicle membrane
NOS2-CD74 complex
lysosomal membrane
ER to Golgi transport vesicle membrane
transport vesicle membrane
macrophage migration inhibitory factor receptor complex
lysosomal lumen

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GO Term
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding, via antigen binding groove
amyloid-beta binding
cytokine receptor activity
cytokine binding
CD4 receptor binding
identical protein binding
protein folding chaperone
nitric-oxide synthase binding

Annotation information from UniProt.

Sequence

MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
66			G49108TO	The O-GlcNAc Database
81			G57321FI	GlyGen
130			G45526EA G93718GY G80075MS G57776ZS G27947YN G80479JV G40206WX G20528HD G87123QX G79666IR G92135MA G98611JV G43734MM G40834TG G43669FQ G22310AV G45395BF G59324HL G20706XG G40926MX G14972EH G43223CG G49642SA G58954YZ G83229XP G08918WF G00912UN G23505EP G83646BJ G46691LC G27126ED G04657PL G27058EU G84452RH G51653BI G43769HG G83460ZZ G37509XX G60033FS G59626AS G08290VR G46503DX G70101JE G80920RR G73968GN G64409MC G83633GK G62765YT G64527OM G88891KO G95865ZB G05724UK G31852PQ G90575OW G39188ZX G41247ZX G50282JC G28681TP G54010QB	UniProt GlyGen GlyConnect
136	N-linked (GlcNAc...) asparagine	19159218	G93718GY G80075MS G57776ZS G68490OW G87123QX G79666IR G92135MA G45395BF G07246CJ G14972EH G43223CG G08918WF G71146HJ G75983OB G00912UN G70441OD G87661QW G83646BJ G96430BV G36442WJ G15664MX G46691LC G27126ED G04657PL G25451PN G27058EU G45495MK G84452RH G83460ZZ G37509XX G60033FS G41071NU G49018RC G35253PZ G72747WU G70619PT G59626AS G46503DX G25079LO G70101JE G80920RR G02886BB G90659AW G64409MC G59924QI G83633GK G62765YT G64527OM G28541PG G31852PQ G90575OW G39446WN G39188ZX G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
148				GlyGen
196			G57321FI	GlyGen
197			G57321FI	GlyGen
203	O-linked (GalNAc...) threonine	22171320 23234360	G29931IJ G43417UB G57321FI	UniProt GlyGen GlyConnect
256	N-linked (GlcNAc...) asparagine	10022822		UniProt GlyGen
270			G75418YA G72747WU G80920RR G90659AW G62765YT G05049YU G31852PQ G23719VF G41247ZX G02815KT	GlycoProtDB GlyGen