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HLA class I histocompatibility antigen, A alpha chain

Summary

UniProt ID

P04439

Gene Symbol

HLA-A
HLAA

Organism

Homo sapiens (human)

External Links

GlyConnect

1324

GlyGen

P04439

PubChem

P04439

The O-GlcNAc Database

P04439

RaftProt

P04439

O-GlcNAcAtlas

P04439

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Innate immunity
MHC I
Phosphoprotein
Reference proteome
Signal
Sulfation
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **11 - 20** of 22 in total

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GO Term
positive regulation of T cell cytokine production
antigen processing and presentation of endogenous peptide antigen via MHC class I
CD8-positive, alpha-beta T cell activation
protection from natural killer cell mediated cytotoxicity
positive regulation of CD8-positive, alpha-beta T cell proliferation
positive regulation of memory T cell activation
positive regulation of CD8-positive, alpha-beta T cell activation
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

Displaying entries **1 - 10** of 19 in total

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GO Term
membrane
MHC class I peptide loading complex
ER to Golgi transport vesicle membrane
phagocytic vesicle membrane
early endosome membrane
recycling endosome membrane
extracellular exosome
endoplasmic reticulum exit site
lumenal side of endoplasmic reticulum membrane
MHC class I protein complex

Displaying **all 8** entries
GO Term
signaling receptor binding
T cell receptor binding
CD8 receptor binding
TAP binding
TAP complex binding
RNA binding
beta-2-microglobulin binding
peptide antigen binding

Annotation information from UniProt.

Sequence

MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
110	N-linked (GlcNAc...) asparagine	19159218	G77669RF G04854VP G92135MA G45395BF G85554PZ G20706XG G40926MX G49642SA G26330YA G40574BA G87389XI G36442WJ G76295SF G15664MX G27126ED G04657PL G83460ZZ G41071NU G49018RC G72747WU G70101JE G80920RR G73968GN G02886BB G62765YT G64527OM G54010QB	UniProt GlyGen GlyConnect
112			G49108TO	The O-GlcNAc Database
359			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens
E3 ubiquitin ligases ubiquitinate target proteins	Homo sapiens
ER-Phagosome pathway	Homo sapiens
Endosomal/Vacuolar pathway	Homo sapiens
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Homo sapiens
Interferon alpha/beta signaling	Homo sapiens
Interferon gamma signaling	Homo sapiens
Nef mediated downregulation of MHC class I complex cell surface expression	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements