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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Receptor tyrosine-protein kinase erbB-2
Summary
- UniProt ID
- P04626
- Gene Symbol
-
- ERBB2
- HER2
- MLN19
- NEU
- NGL
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011368
- GlyConnect
- GlyGen
- P04626
- PubChem
- P04626
- The Human Metabolome Database
- HMDBP01473
- RaftProt
- P04626
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Activator
- Alternative initiation
- Alternative splicing
- Cell membrane
- Cell projection
- Chromosomal rearrangement
- Cytoplasm
- Disease variant
- Disulfide bond
- Endosome
- Glycoprotein
- Nucleus
- Phosphoprotein
- Receptor
- Reference proteome
- Signal
- Transcription regulation
- Transmembrane helix
- Tyrosine-protein kinase
- Gene Ontology (GO)
| GO Term |
|---|
| endosome membrane |
| nucleoplasm |
| early endosome |
| cytosol |
| basal plasma membrane |
| basolateral plasma membrane |
| apical plasma membrane |
| perinuclear region of cytoplasm |
| nucleus |
| plasma membrane |
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 68 | N-linked (GlcNAc...) asparagine |
|
||
| 124 | N-linked (GlcNAc...) asparagine | |||
| 127 |
|
|||
| 187 | N-linked (GlcNAc...) asparagine | |||
| 259 | N-linked (GlcNAc...) asparagine | |||
| 526 |
|
|
||
| 530 | N-linked (GlcNAc...) asparagine | |||
| 571 | N-linked (GlcNAc...) asparagine | |||
| 629 | N-linked (GlcNAc...) asparagine | |||
| 998 |
|
G52890YB
G96577RX
G43417UB
G16125XL
G45395BF
G14972EH
G43223CG
G87661QW
G70101JE
G80920RR
G62765YT
G64527OM
G05724UK
G31852PQ
G39188ZX
G95133RI
G66163OV
G08918WF
G00912UN
G48414YA
G83646BJ
G41071NU
G44215PV
G08290VR
G65184UU
G15169WU
G46524LG
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| PI3K events in ERBB2 signaling | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
| PLCG1 events in ERBB2 signaling | Homo sapiens |
| RAF/MAP kinase cascade | Homo sapiens |
| Resistance of ERBB2 KD mutants to AEE788 | Homo sapiens |
| Resistance of ERBB2 KD mutants to afatinib | Homo sapiens |
| Resistance of ERBB2 KD mutants to lapatinib | Homo sapiens |
| Resistance of ERBB2 KD mutants to neratinib | Homo sapiens |
| Resistance of ERBB2 KD mutants to osimertinib | Homo sapiens |
