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Standards Ontologies Notations
Receptor tyrosine-protein kinase erbB-2

Summary
UniProt ID
P04626
Gene Symbol
  • ERBB2
  • HER2
  • MLN19
  • NEU
  • NGL
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011368
GlyConnect
GlyGen
P04626
PubChem
P04626
The Human Metabolome Database
HMDBP01473
RaftProt
P04626
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Activator
  • Alternative initiation
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Chromosomal rearrangement
  • Cytoplasm
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Nucleus
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Signal
  • Transcription regulation
  • Transmembrane helix
  • Tyrosine-protein kinase
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 10 entries
Position Description PubMed ID GlyTouCan ID Source
68 N-linked (GlcNAc...) asparagine
124 N-linked (GlcNAc...) asparagine
127
187 N-linked (GlcNAc...) asparagine
259 N-linked (GlcNAc...) asparagine
526
530 N-linked (GlcNAc...) asparagine
571 N-linked (GlcNAc...) asparagine
629 N-linked (GlcNAc...) asparagine
998
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 11 - 20 of 30 in total
Pathway Name Organism
PI3K events in ERBB2 signaling Homo sapiens
PI3K/AKT Signaling Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens
PLCG1 events in ERBB2 signaling Homo sapiens
RAF/MAP kinase cascade Homo sapiens
Resistance of ERBB2 KD mutants to AEE788 Homo sapiens
Resistance of ERBB2 KD mutants to afatinib Homo sapiens
Resistance of ERBB2 KD mutants to lapatinib Homo sapiens
Resistance of ERBB2 KD mutants to neratinib Homo sapiens
Resistance of ERBB2 KD mutants to osimertinib Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024