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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Cytochrome P450 1A2
Summary
- UniProt ID
- P05177
- Gene Symbol
-
- CYP1A2
- Organism
- Homo sapiens (human)
External Links
- PubChem
- P05177
- SwissLipids
- The Human Metabolome Database
- HMDBP01560
- RaftProt
- P05177
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Fatty acid metabolism
- Glycoprotein
- Heme
- Lyase
- Membrane
- Microsome
- Monooxygenase
- Reference proteome
- Sterol metabolism
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum membrane |
| intracellular membrane-bounded organelle |
| GO Term |
|---|
| estrogen 2-hydroxylase activity |
| hydroperoxy icosatetraenoate dehydratase activity |
| iron ion binding |
| enzyme binding |
| heme binding |
Sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 69 | O-linked (GlcNAc) serine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Aflatoxin activation and detoxification | Homo sapiens |
| Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 | Homo sapiens |
| Biosynthesis of maresin-like SPMs | Homo sapiens |
| Biosynthesis of protectins | Homo sapiens |
| Methylation | Homo sapiens |
| Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | Homo sapiens |
| Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13515 | tuberous sclerosis | |
| DOID:13548 | secondary Parkinson disease | |
| DOID:13580 | cholestasis | |
| DOID:1380 | endometrial cancer | |
| DOID:14040 | autoimmune polyendocrine syndrome | |
| DOID:14320 | generalized anxiety disorder | |
| DOID:14323 | Marfan syndrome | |
| DOID:14330 | Parkinson's disease | |
| DOID:1443 | cerebral degeneration | |
| DOID:14525 | Reye syndrome |
