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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-galactosidase A
Summary
- UniProt ID
- P06280
- Gene Symbol
-
- GLA
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011404
- GlyConnect
- GlyGen
- P06280
- PubChem
- P06280
- SwissLipids
- The Human Metabolome Database
- HMDBP00723
- The O-GlcNAc Database
- P06280
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lipid metabolism
- Lysosome
- Pharmaceutical
- RNA editing
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| lysosome |
| Golgi apparatus |
| extracellular exosome |
| azurophil granule lumen |
| lysosomal lumen |
| GO Term |
|---|
| catalytic activity |
| signaling receptor binding |
| hydrolase activity |
| galactoside binding |
| protein homodimerization activity |
| alpha-galactosidase activity |
Sequence
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 139 | N-linked (GlcNAc...) asparagine | |||
| 192 | N-linked (GlcNAc...) asparagine | |||
| 215 | N-linked (GlcNAc...) asparagine | |||
|
|
G76417NN
G15169WU
G70232NH
G06247RL
G90382BL
G34989PA
G43669FQ
G47012YE
G45395BF
G37412TK
G75983OB
G00912UN
G48414YA
G83460ZZ
G70101JE
G80920RR
G12313PD
G82463GQ
G62765YT
G62894KT
G11870QZ
G47644PP
G72291OX
G31852PQ
G23719VF
G41247ZX
G74724QE
G92275SC
G28681TP
G23294PN
G01937VC
G05724UK
G39188ZX
G06110VR
G14669DU
G27058EU
G29184RN
G96091TT
G46503DX
G95995BI
G90575OW
G50282JC
G00406II
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110756 | type 1 diabetes mellitus 19 | |
| DOID:0110757 | type 1 diabetes mellitus 20 | |
| DOID:0110758 | type 1 diabetes mellitus 21 | |
| DOID:0110759 | type 1 diabetes mellitus 22 | |
| DOID:0110760 | type 1 diabetes mellitus 23 | |
| DOID:0110761 | type 1 diabetes mellitus 24 | |
| DOID:0111040 | glycogen storage disease IXd | |
| DOID:0111041 | glycogen storage disease IXb | |
| DOID:0111042 | glycogen storage disease IXa | |
| DOID:0111043 | glycogen storage disease IXc |
