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Receptor tyrosine-protein kinase erbB-2

Summary

UniProt ID

P06494

Gene Symbol

Erbb2
Neu

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P06494
PubChem: P06494

Annotation

Keyword

3D-structure
ATP-binding
Activator
Cell membrane
Cell projection
Cytoplasm
DNA-binding
Disulfide bond
Endosome
Glycoprotein
Nucleus
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Signal
Transcription regulation
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

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GO Term
response to axon injury
semaphorin-plexin signaling pathway
phosphatidylinositol 3-kinase/protein kinase B signal transduction
estrous cycle
positive regulation of transcription by RNA polymerase I
response to xenobiotic stimulus
positive regulation of Ras protein signal transduction
liver development
positive regulation of protein phosphorylation
signal transduction

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GO Term
early endosome
basal plasma membrane
ruffle membrane
ERBB3:ERBB2 complex
presynaptic membrane
perinuclear region of cytoplasm
nucleus
cytoplasm
plasma membrane
microvillus

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GO Term
Hsp90 protein binding
ubiquitin protein ligase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
RNA polymerase I core binding
coreceptor activity
receptor tyrosine kinase binding
ATP binding
DNA binding

Annotation information from UniProt.

Sequence

MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	Source
68	N-linked (GlcNAc...) asparagine		UniProt GlyGen
188	N-linked (GlcNAc...) asparagine		UniProt GlyGen
260	N-linked (GlcNAc...) asparagine	12610629	UniProt GlyGen
532	N-linked (GlcNAc...) asparagine		UniProt GlyGen
573	N-linked (GlcNAc...) asparagine		UniProt GlyGen
631	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 14** of 14 in total

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Pathway Name	Organism
RAF/MAP kinase cascade	Rattus norvegicus
SHC1 events in ERBB2 signaling	Rattus norvegicus
Sema4D induced cell migration and growth-cone collapse	Rattus norvegicus
Signaling by ERBB2	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements