GlyCosmos Portal

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Prosaposin

Summary

UniProt ID

P07602

Gene Symbol

PSAP
GLBA
SAP1

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011421

GlyConnect

1645

GlyGen

P07602

PubChem

P07602

The Human Metabolome Database

HMDBP01673

The O-GlcNAc Database

P07602

RaftProt

P07602

O-GlcNAcAtlas

P07602

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Gangliosidosis
Gaucher disease
Glycoprotein
Lysosome
Metachromatic leukodystrophy
Neurodegeneration
Parkinson disease
Parkinsonism
Reference proteome
Repeat
Secreted
Signal
Sphingolipid metabolism

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
sphingolipid metabolic process
lysosomal transport
regulation of autophagy
regulation of lipid metabolic process
prostate gland growth
epithelial cell differentiation involved in prostate gland development
positive regulation of beta-galactosidase activity
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
ganglioside GM1 transport to membrane

Displaying entries **1 - 10** of 11 in total

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GO Term
extracellular region
extracellular space
lysosome
lysosomal membrane
plasma membrane
intracellular membrane-bounded organelle
collagen-containing extracellular matrix
azurophil granule membrane
extracellular exosome
late endosome

Displaying entries **1 - 10** of 11 in total

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GO Term
protease binding
enzyme activator activity
identical protein binding
protein homodimerization activity
phospholipid binding
scaffold protein binding
ganglioside GM1 binding
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GT1b binding

Site Annotations

Displaying 1 entry
Position	Description
215	Not glycosylated; in variant MLDSAPB Ile-217

Annotation information from UniProt.

Sequence

MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 23 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
80	N-linked (GlcNAc...) asparagine	19159218 19167329 2842863	G53075ES G69834CE G67164EE G50856PC G32788FZ G63136LV G05962QB G76417NN G15169WU G70232NH G69521XL G06247RL G35541EV G34617SM G93718GY G13131HA G49755GI G77582RK G80075MS G57776ZS G16125XL G29545VG G44753VC G68490OW G86880BF G27947YN G90382BL G30970QQ G30248BL G63889NK G80479JV G67031OU G85282JO G20528HD G96577RX G79666IR G92135MA G34989PA G40834TG G43669FQ G45395BF G07246CJ G85554PZ G40926MX G14972EH G43223CG G37412TK G40574BA G08918WF G00912UN G48414YA G27915IV G87389XI G45359RY G70441OD G86357DX G87661QW G83646BJ G76295SF G46691LC G27126ED G04657PL G25451PN G27058EU G45495MK G84452RH G46524LG G83460ZZ G96091TT G37509XX G70223PD G79809MM G41071NU G07755XJ G86182NS G35253PZ G70619PT G59626AS G08290VR G14994KB G46503DX G41840AI G01650EU G70101JE G80920RR G63041LO G01485JJ G42124LM G78059CC G90659AW G77547TA G45504EY G64409MC G59924QI G29299MO G37399XV G82463GQ G20030CU G83633GK G62765YT G64527OM G47950XN G62894KT G11870QZ G47644PP G72791KH G88891KO G43299SD G61207RZ G95177YH G05049YU G28541PG G72735IY G18647XP G55383ZG G85269DF G72291OX G95865ZB G31852PQ G96993FE G90575OW G89993FE G23719VF G80858MF G11314AS G12398HZ G29880MM G39188ZX G41247ZX G80966KZ G50282JC G35029YA G57776ZU G36379GD G02815KT G06110VR G84349RE G57317CE G60145BJ G09724ZC G92050GC G74724QE G82348BZ G92275SC G14669DU G28681TP G89045VA	GlycoProtDB UniProt GlyGen GlyConnect
82			G49108TO	GlyGen The O-GlcNAc Database
93			G49108TO	GlyGen The O-GlcNAc Database
101	N-linked (GlcNAc...) asparagine	19159218 19167329 2842863	G53075ES G81637OR G82443XX G05962QB G64394MX G18183SM G76417NN G15169WU G70232NH G57888GL G69521XL G35541EV G93718GY G77582RK G20312EM G80075MS G11629QQ G57776ZS G16125XL G68490OW G86880BF G27947YN G90382BL G63889NK G80479JV G90093AU G85282JO G20528HD G87123QX G79666IR G65019XG G92135MA G43734MM G75607BQ G34989PA G81198YO G40834TG G43669FQ G47012YE G08146BT G22310AV G45395BF G07246CJ G85554PZ G10819WX G14972EH G22625SJ G43223CG G95977AE G37412TK G40574BA G08918WF G75983OB G00912UN G48414YA G27915IV G11911BT G45359RY G70441OD G86357DX G70822IO G83646BJ G76295SF G04657PL G25451PN G08293MJ G27058EU G45495MK G84452RH G39619TI G83460ZZ G79809MM G41071NU G47448YK G46503DX G70101JE G80920RR G42124LM G78059CC G90659AW G45504EY G84820NF G12313PD G27622TD G29299MO G37399XV G82463GQ G20030CU G62765YT G64527OM G03930BU G47950XN G62894KT G11870QZ G47644PP G43299SD G61207RZ G95177YH G05049YU G85269DF G72291OX G95865ZB G31852PQ G72787SB G89993FE G23719VF G80858MF G12398HZ G29880MM G41247ZX G80966KZ G25637MV G06110VR G57317CE G09724ZC G92050GC G74724QE G82348BZ G92275SC G14669DU G28681TP G84225JN	GlycoProtDB UniProt GlyGen GlyConnect
103			G49108TO	GlyGen The O-GlcNAc Database
105			G49108TO	GlyGen The O-GlcNAc Database
136			G47518TP G48414YA	GlyGen GlyConnect
214			G74724QE G49108TO	GlyGen The O-GlcNAc Database GlyConnect
215	N-linked (GlcNAc...) (complex) asparagine	11180632 19167329	G53075ES G82443XX G76417NN G15169WU G70232NH G79286RS G34617SM G37881RL G20312EM G80075MS G11629QQ G57776ZS G86795LJ G90382BL G91473PK G63889NK G56784JY G87123QX G96577RX G79666IR G81263BG G75607BQ G34989PA G81198YO G18938DW G47012YE G22310AV G45395BF G88374WZ G14972EH G43223CG G83229XP G08918WF G75983OB G00912UN G48414YA G45359RY G70441OD G86357DX G87661QW G83646BJ G72667IM G76295SF G25418HZ G04657PL G25451PN G87051GH G27058EU G84452RH G83460ZZ G29857RC G79809MM G41071NU G45187EI G61792ET G07755XJ G86182NS G47448YK G08290VR G14994KB G25079LO G48584BU G70101JE G80920RR G01485JJ G42124LM G04483SK G07695ZT G42264OV G52428MJ G78059CC G90659AW G77547TA G45504EY G64409MC G80333GO G59924QI G62765YT G64527OM G62894KT G47644PP G95177YH G00986YT G03216SJ G28347RJ G36191CD G43664YB G05049YU G28541PG G72735IY G85269DF G95865ZB G31852PQ G90575OW G66937TJ G81397LO G83006TR G89993FE G23719VF G33609NS G04744XB G11314AS G12398HZ G33734YD G61334IA G41247ZX G50282JC G30633FJ G39213VZ G42679AH G28663KH G39602UU G56269EA G69411IG G11994QC G36379GD G45036WQ G02815KT G84349RE G29905OR G85041WE G92050GC G20956ZV G74724QE G82348BZ G92275SC G14669DU G28681TP G00395TQ G31685JQ G64581RP G89045VA	GlycoProtDB UniProt GlyGen GlyConnect
216			G31685JQ G49108TO	GlyGen The O-GlcNAc Database GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
G alpha (i) signalling events	Homo sapiens
Glycosphingolipid catabolism	Homo sapiens
Neutrophil degranulation	Homo sapiens
Peptide ligand-binding receptors	Homo sapiens
Platelet degranulation	Homo sapiens

Human Protein Atlas

ENSG00000197746

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **161 - 170** of **265** in total

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DO ID	Disease Name	Source
DOID:0110729	neuronal ceroid lipofuscinosis 6A	DisGeNET
DOID:0110730	neuronal ceroid lipofuscinosis 6B	DisGeNET
DOID:0110731	neuronal ceroid lipofuscinosis 3	DisGeNET
DOID:0110732	neuronal ceroid lipofuscinosis 11	DisGeNET
DOID:0110733	neuronal ceroid lipofuscinosis 9	DisGeNET
DOID:0110957	Gaucher's disease type I	DisGeNET
DOID:0110961	atypical Gaucher's disease due to saposin c deficiency	Glyco-Disease Genes Database DisGeNET
DOID:0111330	combined saposin deficiency	Glyco-Disease Genes Database DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Acknowledgements