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Thrombospondin-1

Summary

UniProt ID

P07996

Gene Symbol

THBS1
TSP
TSP1

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011431

GlyConnect

GlyGen

P07996

PubChem

P07996

The O-GlcNAc Database

P07996

RaftProt

P07996

O-GlcNAcAtlas

P07996

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Apoptosis
Calcium
Cell adhesion
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Extracellular matrix
Glycoprotein
Heparin-binding
Inflammatory response
Reference proteome
Repeat
Sarcoplasmic reticulum
Signal
Unfolded protein response

Gene Ontology (GO)

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GO Term
negative regulation of endothelial cell proliferation
chronic inflammatory response
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
apoptotic process
inflammatory response
immune response
cell adhesion
positive regulation of cell population proliferation
negative regulation of cell population proliferation

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GO Term
extracellular region
fibrinogen complex
extracellular space
secretory granule
extracellular matrix
collagen-containing extracellular matrix
external side of plasma membrane
cell surface
sarcoplasmic reticulum
extracellular exosome

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GO Term
proteoglycan binding
fibrinogen binding
protein homodimerization activity
endopeptidase inhibitor activity
phosphatidylserine binding
fibronectin binding
fibroblast growth factor binding
integrin binding
extracellular matrix structural constituent
protease binding

Annotation information from UniProt.

Sequence

MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
150			G49108TO	GlyGen The O-GlcNAc Database
248	N-linked (GlcNAc...) asparagine	16263699 16335952 18065761	G70232NH G37818NZ G93718GY G11629QQ G57776ZS G60834IK G86880BF G27947YN G28622IK G90382BL G80479JV G85282JO G87123QX G79666IR G81263BG G92135MA G98611JV G43734MM G34989PA G81198YO G40834TG G02528FI G43669FQ G22310AV G45395BF G59324HL G07246CJ G20706XG G10819WX G14972EH G43223CG G95977AE G37412TK G10846ZT G40574BA G82830MN G00273SJ G08918WF G00912UN G99966GV G92551JA G08110WX G61256FT G70441OD G87661QW G83646BJ G17208MA G72667IM G76295SF G46691LC G80223IX G25418HZ G27126ED G04657PL G25451PN G27058EU G84452RH G83460ZZ G51640FO G70223PD G60033FS G41071NU G07755XJ G72747WU G70619PT G59626AS G73430PD G08290VR G14994KB G92406TI G73968GN G42124LM G65092SV G23863VK G90659AW G77547TA G65000LJ G64409MC G62765YT G47644PP G05049YU G90575OW G11314AS G84225JN	UniProt GlyGen GlyConnect
289			G57321FI	GlyGen
292			G57321FI	GlyGen
293			G57321FI	GlyGen
300			G57321FI	GlyGen
302			G57321FI	GlyGen
360	N-linked (GlcNAc...) asparagine		G13910DJ G12341GU G70232NH G93718GY G80075MS G57776ZS G60834IK G86880BF G27947YN G28622IK G90382BL G80479JV G20528HD G87123QX G96577RX G79666IR G81263BG G92135MA G98611JV G34989PA G81198YO G40834TG G43669FQ G47012YE G08146BT G22310AV G45395BF G70375MX G85554PZ G10819WX G40926MX G14972EH G22625SJ G02030ZB G43223CG G60177UT G40574BA G82830MN G00273SJ G08918WF G00912UN G48414YA G70441OD G72797UR G87661QW G83646BJ G63381RX G72667IM G76295SF G66621EA G46691LC G80223IX G25418HZ G27126ED G04657PL G25451PN G87051GH G27058EU G45495MK G84452RH G24528MX G39619TI G43769HG G83460ZZ G51640FO G70223PD G20425TQ G60033FS G41071NU G91636VS G07755XJ G46902YN G72747WU G44215PV G70619PT G06356OH G59626AS G08290VR G92406TI G20210JR G41840AI G01650EU G23294PN G70101JE G80920RR G63041LO G01485JJ G73968GN G65184UU G79568CQ G03382KH G42124LM G02886BB G65092SV G23863VK G90659AW G74430RZ G45504EY G65000LJ G59924QI G12313PD G29299MO G37399XV G82463GQ G14260UH G62765YT G64527OM G47950XN G11870QZ G47644PP G23432EQ G72790NZ G10256JP G95177YH G10486CT G50045TK G05049YU G46687AB G28541PG G72735IY G18647XP G82119TF G85269DF G72291OX G95865ZB G05724UK G31852PQ G49874UX G33609NS G39446WN G11314AS G29880MM G39188ZX G41247ZX G23453IV G57776ZU G02815KT G06110VR G33584ML	GlycoProtDB UniProt GlyGen GlyConnect
385	C-linked (Man) tryptophan	11067851	G70323CJ	UniProt GlyGen
394	O-linked (Fuc...) serine	11067851	G06038KF	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Defective B3GALTL causes PpS	Homo sapiens
Integrin cell surface interactions	Homo sapiens
O-glycosylation of TSR domain-containing proteins	Homo sapiens
Platelet degranulation	Homo sapiens
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Homo sapiens
Signaling by PDGF	Homo sapiens
Syndecan interactions	Homo sapiens

Human Protein Atlas

ENSG00000137801

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements